ABSTRACT The prevalence of postmenopausal osteoporosis (PMOP) has been steadily increasing. Ferroptosis has been recognized as a critical factor influencing the bone‐forming ability of bone marrow mesenchymal stem cells (BMSCs). Valproic acid (VPA), an HDAC inhibitor, has been suggested to play a role in regulating osteoporosis development; however ...
Qing‐Song Gu +8 more
wiley +1 more source
Comparing Teriparatide and Bisphosphonates for Postmenopausal Osteoporosis: A Systematic Review and Meta-Analysis of RCTs. [PDF]
Uddin MZ +11 more
europepmc +1 more source
SIRT Family: Biological Functions and Therapeutic Targets
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang +9 more
wiley +1 more source
ABSTRACT The regeneration of osteoporotic bone defects is severely hampered by compromised endogenous healing capacity, demanding advanced strategies that actively orchestrate pro‐osteogenic microenvironments. Here, we report an integrated, self‐powered osteo‐regenerative system that uniquely leverages a dual ultrasound‐responsive piezoelectric ...
Bing Tan +6 more
wiley +1 more source
Romosozumab and Denosumab Combination Therapy After Denosumab in Postmenopausal Osteoporosis. [PDF]
Adami G +10 more
europepmc +1 more source
Staging concept for aging management: Definition, mechanism, and coping strategies
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang +6 more
wiley +1 more source
Combined Nanoparticle-Based Delivery of Estrogens and Raloxifen in Postmenopausal Osteoporosis. [PDF]
Włodarczyk A, Dolibog P.
europepmc +1 more source
Menopausal hormone therapy after ovarian cancer: A 10‐year survival analysis in premenopausal women
Among premenopausal women surgically treated for ovarian cancer, no difference in 10‐year overall survival was observed between postoperative MHT users and non‐users. Young ovarian cancer survivors should be recommended MHT after surgically induced menopause.
Åsa Ehlin von Kartaschew +4 more
wiley +1 more source
Association between the nutritional risk index and postmenopausal osteoporosis in patients with type 2 diabetes mellitus. [PDF]
Haibier A, Lin H, Liu W, Li W.
europepmc +1 more source
The association between glutathione reductase and postmenopausal osteoporosis: a retrospective study. [PDF]
Wang J +13 more
europepmc +1 more source

