Results 81 to 90 of about 282,351 (359)

Current medical treatment of estrogen receptor-positive breast cancer [PDF]

, 2015
Approximately 80% of breast cancers (BC) are estrogen receptor (ER)-positive and thus endocrine therapy (ET) should be considered complementary to surgery in the majority of patients.
Basso, S. M. M., Lumachi, Franco, Santeufemia, D. A.   +2 more
core   +1 more source

Bone Health and Pubertal Induction in Turner Syndrome: The Possibility of Earlier Transdermal Lower‐Dose Estradiol Therapy for Healthy Bone Density and Quality

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT The effect of estrogen deficiency on bone health in Turner syndrome (TS) may be a concern even before adulthood. Previous guidelines have discussed hormone replacement therapy (HRT) in children with TS. However, some practical issues related to puberty induction in TS require clarification, such as how to implement HRT to achieve adequate bone
Yukihiro Hasegawa, Kento Ikegawa, Takeshi Munenaga, Tomoyo Itonaga, Marie Mitani‐Konno, Masanobu Kawai, Naoko Amano   +6 more
wiley   +1 more source

Background risk of breast cancer and the association between physical activity and mammographic density [PDF]

, 2015
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if ...
A McTiernan, A McTiernan, A McTiernan, AH Eliassen, Arvid Sjölander, B Sternfeld, BE Ainsworth, CC Siozon, CG Woolcott, CM Friedenreich, CM Vachon, CM Vachon, DG Evans, F Bray, GA Greendale, Hatef Darabi, I Thune, J Stone, J Tyrer, JA Cauley, JA Shepherd, Jack Cuzick, JL Kelsey, JS Brand, Judith S Brand, JW Byng, K Walker, Kamila Czene, Katarina Bälter, KP Suijkerbuijk, KW Reeves, L Bernstein, L Bernstein, L Yaghjyan, LH Kushi, M Clemons, MC Pike, Mikael Eriksson, ML Irwin, ML Irwin, MP Warren, N Oestreicher, N Orsini, NF Boyd, NF Boyd, Per Hall, PM Janiszewski, R Highnam, RZ Stolzenberg-Solomon, SA Qureshi, SE Bonn, SS Maruti, SS Tworoger, SS Tworoger, Stephanie E Bonn, Thang Trinh, TM Peters, VA McCormack, WC Miller, Y Bremnes, Y Wu   +60 more
core   +2 more sources

Vitamin D‐induced mechanisms in cancer prevention and therapy: Recent advances and future opportunities

Animal Models and Experimental Medicine, EarlyView.
Vitamin D, traditionally known to promote calcium and bone health, is being explored for its role in cancer prevention and treatment through its influence on cell proliferation, differentiation, apoptosis, and immune response. The vitamin D receptor (VDR) regulates gene expression and interacts with key signaling pathways such as Wnt/β‐catenin, MAPK ...
D. Prasanth, Pathan Amanulla Khan, Jamal‐E‐Fatima, Trupti Pratik Durgawale, Falak Arjumand Siddique, Sharuk L. Khan, Azmath Farhana, Uttam Prasad Panigrahy, Mohammed Abdul Aziz shahid, Mohammed Sayeed, Md. Faysal   +10 more
wiley   +1 more source

Effect of Menopause on Quality of Life and Psychological Profile of Women in Gorgan, Iran

Journal of Clinical and Basic Research, 2018
Introduction: Menopause is an important event accompanied with significant hormonal changes that have permanent and irreversible effects on women’s lives.
Soheyla Kalantari, Fatemeh Heidari Lahsher, Ramezan Hassanzadeh   +2 more
doaj  

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, EarlyView.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

Relationship between parity and the prevalence of chronic kidney disease in Japan considering hypertensive disorders of pregnancy and body mass index

BMC Nephrology
Background Global studies exploring the relationship between parity and chronic kidney disease (CKD) are scarce. Furthermore, no study has examined the relationship between parity and CKD in Japan.
Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito   +14 more
doaj   +1 more source

Pharmacokinetics, Tolerability, and Biomarker Profile of the Neurokinin 3 Receptor Antagonist Fezolinetant in Healthy Japanese Individuals: A 2‐Part, Randomized, Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This 2‐part, randomized, placebo‐controlled, double‐blind, Phase 1 study analyzed the pharmacokinetics, safety, and biomarker profile of fezolinetant in healthy Japanese individuals. Part 1: male participants received single doses of placebo or fezolinetant 15 or 60 mg.
Akira Koibuchi, Megumi Iwai, Kanji Komatsu, Kentaro Kuroishi, Mai Shibata, Masako Saito, Jace Nielsen, Jiayin Huang, Shunji Matsuki   +8 more
wiley   +1 more source

Estrogenic activity, race/ethnicity, and Indigenous American ancestry among San Francisco Bay Area women. [PDF]

, 2019
Estrogens play a significant role in breast cancer development and are not only produced endogenously, but are also mimicked by estrogen-like compounds from environmental exposures.
Fejerman, Laura, Gomez, Scarlett L, John, Esther M, Sanchez, Sylvia S, Smith, Martyn T, Stanczyk, Frank Z, Tachachartvanich, Phum   +6 more
core   +2 more sources

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Bexicaserin in Healthy Participants: A First‐in‐Human Randomized, Double‐Blind, Placebo‐Controlled Single Ascending Dose Escalation Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective 5‐hydroxytryptamine 2C (5‐HT2C) superagonist in development for the treatment of seizures in developmental and epileptic encephalopathies (DEEs). This double‐blind, placebo‐controlled, single ascending dose (SAD) Phase 1 study aimed to assess the safety, tolerability, and pharmacokinetic (PK) and ...
Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R Srinivas, Randall Kaye   +6 more
wiley   +1 more source