Results 81 to 90 of about 290,213 (358)

Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Fezolinetant is a first‐in‐class, selective, non‐hormonal, neurokinin 3 receptor antagonist that is approved for the treatment of moderate to severe vasomotor symptoms due to menopause. In a phase 2b clinical study (n = 352), nine study participants experienced elevations in serum transaminases exceeding three times the upper limit of normal.
Jace C. Nielsen   +11 more
wiley   +1 more source

Adherence to adjuvant therapy in post-menopausal breast cancer patients: A review [PDF]

open access: yes, 2011
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 John Wiley & Sons, IncThis review aimed to address the concept of adherence to adjuvant therapy in post-menopausal women.
Banning, M
core   +1 more source

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

open access: yesFood Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi   +4 more
wiley   +1 more source

Effect of Menopause on Quality of Life and Psychological Profile of Women in Gorgan, Iran

open access: yesJournal of Clinical and Basic Research, 2018
Introduction: Menopause is an important event accompanied with significant hormonal changes that have permanent and irreversible effects on women’s lives.
Soheyla Kalantari   +2 more
doaj  

Relationship between parity and the prevalence of chronic kidney disease in Japan considering hypertensive disorders of pregnancy and body mass index

open access: yesBMC Nephrology
Background Global studies exploring the relationship between parity and chronic kidney disease (CKD) are scarce. Furthermore, no study has examined the relationship between parity and CKD in Japan.
Hongxin Wang   +14 more
doaj   +1 more source

The effects of hormone replacement therapy on mammographic density among postmenopausal women in Hospital Raja Perempuan Zainab Ii, Kota Bharu, Kelantan. [PDF]

open access: yes, 2011
Introduction Hormone replacement therapy (HRT) is commonly prescribed to postmenopausal women to improve their postmenopausal symptoms. Postmenopausal hormone use is associated with increase in mammographic density and increased incidence of breast pain.
Kamaravel, Shanti
core  

Tocotrienols: A Review From Source to Therapeutic Applications

open access: yesFood Frontiers, EarlyView.
Tocotrienols demonstrate superior antioxidant, neuroprotective, and anti‐inflammatory properties compared to conventional vitamin E forms, with promising therapeutic applications across multiple disorders when delivered through optimized systems that enhance their inherently limited bioavailability.
Natalia‐Carolina Londoño   +6 more
wiley   +1 more source

Managing menopausal symptoms and associated clinical issues in breast cancer survivors [PDF]

open access: yes, 2017
Objective: Review evidence to guide management of menopausal signs and symptoms in women after breast cancer and make recommendations accordingly. Evidence: Randomized controlled clinical trials, observational studies, evidence-based guidelines, and
Davis, Susan R.   +5 more
core   +1 more source

Milk Extracellular Vesicles and Their Functional Potential in Osteoblast Activity: A Cross‐Species Comparison for Nutraceutical Development

open access: yesFood Frontiers, EarlyView.
Label: mEVs and osteogenesis Description: This study reports a comparative analysis of mEVs isolated from raw milk EVs. Functional relevance of each type of mEVs is evaluated on cell proliferation and osteogenic differentiation of murine fibroblasts model.
Anna Maria Grimaldi   +6 more
wiley   +1 more source

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