Results 31 to 40 of about 96,611 (262)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Postmortem Ocular Findings in the Optical Coherence Tomography Era: A Proof of Concept Study Based on Six Forensic Cases

Diagnostics, 2021
Postmortem analysis of the ocular globe is an important topic for forensic pathology and transplantology. Although crucial elements may be gathered from examining cadaveric eyes, the latter do not routinely undergo in-depth analysis.
Matteo Nioi, Pietro Emanuele Napoli, Roberto Demontis, Emanuela Locci, Maurizio Fossarello, Ernesto d’Aloja   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Feasibility of an Isolated Kidney Perfusion Model for Postmortem Interval Estimation in a Rabbit Model: A Pilot Study

Diagnostics
Background: The estimation of the postmortem interval (PMI) remains a complex challenge in forensic medicine. While macroscopic, biochemical, and molecular methods are well-documented, postmortem functional approaches at the organ level are largely ...
Ramazan Temürkol, Hülya Güler, Ahsen Kaya, Orhan Fahri Demir, Meltem Kocamanoğlu, Yasemin Akçay, Ayşegül Keser   +6 more
doaj   +1 more source

An investigation of postmortem urotensin II receptor levels in brain and kidney tissues in a rat model of cardiac ischemia

Journal of Forensic Science and Medicine, 2018
This study aimed to investigate changes in postmortem urotensin II receptor (UTR) levels in brain and kidney tissues in a rat model of cardiac ischemia. The rats were divided into two groups: a control group and a cardiac ischemia-induced group.
Mustafa Talip Sener, Erol Akpinar, Elif Cadirci, Zekai Halici, Irfan Cinar, Ahmet Nezih Kok   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Impact of high intensity ultrasound on the quality and preservation period of blue shrimp (Litopenaeus stylirostris) muscle

Journal of Fisheries
Due to the limited shelf life of aquatic products, the use of advanced technologies to extend their freshness has become more popular recently. This study aimed to assess the impact of high-intensity ultrasound (HIU) on the quality of blue shrimp ...
Wilfrido Torres-Arreola, Rey Partida-Rivera, Victor M. Ocaño-Higuera, Saúl Ruíz-Cruz, Guadalupe Miroslava Suarez-Jimenez, Nathaly Montoya-Camacho, José Carlos Rodríguez-Figueroa, Enrique Márquez-Rios   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Yoğun Bakım Hemşireleri: Ölümün İlk Tanıkları

Yoğun Bakım Hemşireliği Dergisi
Ölüm, yaşamın ve fiziksel varlığın sona erdiği bir durumu ifade eder. Klinik ölüm, hücresel ölüm, agoni (can çekişme), yalancı ölüm ve beyin ölümü gibi kavramların ayırt edilmesi sağlık çalışanları için önem arz etmektedir.
Halil İlhan Aydoğdu, Esra Özkan
doaj   +1 more source

Histological and miRNAs postmortem changes in incisional wound

Egyptian Journal of Forensic Sciences, 2019
Background Regarding postmortem estimation, the evaluation of early histological and miRNA molecular changes have been of great concerns among forensic scientists due to uncertainty of known conventional methods.
Samah F. Ibrahim, Mona M. Ali, Hoda Basyouni, Laila A. Rashed, Eman A. E. Amer, Dalia Abd El-Kareem   +5 more
doaj   +1 more source