Results 41 to 50 of about 96,611 (262)

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

RELATION OF POSTMORTEM CHANGES DEVELOPMENT AND EXACT POSTMORTEM INTERVAL

open access: yesInter Collegas, 2020
RELATION OF POSTMORTEM CHANGES DEVELOPMENT AND EXACT POSTMORTEM INTERVAL Grygorian E., Olkhovsky V., Gubin M. Purpose: Precise postmortem interval’s evaluation is crucial in cases when violent types of death are suspected by forensic medical examiner.
E. Grygorian, V. Olkhovsky, M. Gubin
openaire   +2 more sources

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

A Systematic Review About Postmortem Pink Teeth: Forensic Classification, Diagnostic Value, and Analysis Methods

open access: yesDiagnostics
Background: The phenomenon of pink teeth represents a notable observation in forensic science, although its interpretation remains complex and not directly attributable to a specific cause of death. Methods: This systematic review provides an updated and
Isabella Aquila   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Research Progress on Postmortem Changes of Computed Tomography Imaging Characteristics on Corpses [PDF]

open access: yesFayixue Zazhi, 2019
Postmortem changes on corpses appear immediately after death, and can transform the original structure characteristics of the corpse to different degrees as well as show specific changes on computed tomography (CT) images, sometimes with false positives ...
DONG He-wen, SUN Yi, QIAN Hui, et al.
doaj   +1 more source

Metagenomic identification of pathogenic bacteria for pneumonia from postmortem lung tissue

open access: yesHuman Pathology Reports, 2022
Pathologists have been concerned about the validity of bacterial cultures from lung tissue for the postmortem identification of pneumonia-associated pathogens. Therefore, we studied whether pathogenic bacteria that cause pneumonia could be identified via
Hidenori Yoshizawa   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

THE ESTIMATION OF THE TIME SINCE DEATH

open access: yesZdravniški Vestnik, 2002
Background. The retrograde estimation of the time since death is still unsuccessfully solved problem in forensic medicine. The registration of the time of death is the principle task of every coroner.
Peter Kadiš
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

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