Results 41 to 50 of about 75,138 (262)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Gambaran Histologik Otot Jantung Pada Hewan Coba Postmortem [PDF]

, 2016
: Commonly, unnatural death is complicated and causes difficulties for to the investigating officers to reveal the modus operandi and the time of death.
Kalangi, S. J. (Sonny), Ubruangge, T. (Tonci), Wangko, S. (Sunny)   +2 more
core  

A Systematic Review About Postmortem Pink Teeth: Forensic Classification, Diagnostic Value, and Analysis Methods

Diagnostics
Background: The phenomenon of pink teeth represents a notable observation in forensic science, although its interpretation remains complex and not directly attributable to a specific cause of death. Methods: This systematic review provides an updated and
Isabella Aquila, Saverio Gualtieri, Aurora Princi, Matteo Antonio Sacco   +3 more
doaj   +1 more source

Review of Postmortem Protein Oxidation in Skeletal Muscle and the Role of the Peroxiredoxin Family of Endogenous Antioxidants

Meat and Muscle Biology, 2023
The development of fresh meat quality is dictated by biochemical changes during the perimortem and postmortem period. Lipid and protein oxidation in postmortem skeletal muscle and meat products is detrimental to product quality.
Brian M Patterson, Elisabeth J. Huff-Lonergan, Logan G Johnson, Steven M. Lonergan   +3 more
doaj   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gambaran Histologik Ginjal Hewan Coba Postmortem [PDF]

, 2014
: Estimation of postmortem interval plays some significant roles in medicolegal investigation. This was a descriptive experimental study using one local pig as model. Samples were taken from the right and left kidneys at several time intervals: 0 minute,
Kalangi, S. J. (Sonny), Rahmadana, B. (Baldatun), Wangko, S. (Sunny)   +2 more
core  

Biochemistry Changes That Occur after Death: Potential Markers for Determining Post-Mortem Interval [PDF]

, 2013
Death is likely to result in very extensive biochemical changes in all body tissues due to lack of circulating oxygen, altered enzymatic reactions, cellular degradation, and cessation of anabolic production of metabolites.
Donaldson, Andrea
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Postmortem imaging of blood and its characteristics using MSCT and MRI [PDF]

, 2018
The rapid development of computed tomography (CT) and magnetic resonance imaging (MRI) led to the introduction and establishment in postmortem investigations.
Aghayev, E., Dirnhofer, R., Jackowski, C., Sonnenschein, M., Thali, M., Vock, P., Yen, K., Zwygart, K.   +7 more
core  

The effects of death and post-mortem cold ischemia on human tissue transcriptomes [PDF]

, 2018
Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels.
Aguet, François, Amador, Raziel, Amadoz, Alicia, Ardlie, Kristin G., Breschi, Alessandra, 1988-, Carbonell-Caballero, Jose, Curado, Joao, Dopazo, Joaquín, Ferreira, Pedro G., Godinho, Caio P. Sá, Guigó Serra, Roderic, Hidalgo, Marta R., Muñoz-Aguirre, Manuel, Nurtdinov, Ramil, Oliveira, Carla, Oliveira, Patrícia, Pervouchine, Dmitri D., Reverter, Ferran, Sammeth, Michael, Sodaei, Reza, 1988-, Sousa, Abel, Çubut, Cankut   +21 more
core   +5 more sources