Results 71 to 80 of about 62,674 (305)

Translocator protein in late stage Alzheimer\u27s disease and Dementia with Lewy bodies brains [PDF]

, 2019
OBJECTIVE: Increased translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), in glial cells of the brain has been used as a neuroinflammation marker in the early and middle stages of neurodegenerative diseases, such
Bales, Kelly R, Benzinger, Tammie L S, Holtzman, David M, Mach, Robert H, Morris, John C, Perrin, Richard J, Sun, Jianjun, Xu, Jinbin   +7 more
core   +2 more sources

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

MORPHOLOGICAL FEATURES OF THE UTERUS IN WOMEN AT DIFFERENT TIME INTERVALS OF THE POSTMORTEM PERIOD AS DIAGNOSTIC CRITERIA FOR ESTABLISHING THE POSTMORTEM INTERVAL

Wiadomości Lekarskie, 2021
The aim is to identify the morphological features of the uterus layers in women at different time intervals of the postmortem period as diagnostic criteria for establishing the postmortem interval. Materials and methods: In the study we used surgical and autopsy material – uterine tissue fragments. All materials were divided into two groups.
Vasil O, Olkhovsky, Edgar K, Grygorian, Mykhailo S, Myroshnychenko, Sergii V, Kozlov, Kostiantyn M, Suloiev, Anton O, Polianskyi, Petro A, Kaplunovskyi, Yuliia Ya, Fedulenkova, Iryna V, Borzenkova   +8 more
openaire   +2 more sources

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Post-Mortem Interval Estimation Based on Insect Evidence: Current Challenges

Insects, 2021
During death investigations insects are used mostly to estimate the post-mortem interval (PMI). These estimates are only as good as they are close to the true PMI.
Szymon Matuszewski
doaj   +1 more source

Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression [PDF]

, 2015
The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD.
Argibay, Pablo, Bassi, Sabrina Cecilia, Seney, Marianne L., Sibille, Etienne   +3 more
core   +1 more source

An Overview on Estimation of Postmortem Interval

, 2023
Throughout the history of forensic medicine, the postmortem interval (PMI) has been one of the commonly and thoroughly investigated problems. Despite many decades of research, accuracy in estimation of the time of death has not significantly improved and no single method can be reliably used to accurately estimate the time of death.
openaire   +3 more sources

HMGB1: A new marker for estimation of the postmortem interval

Experimental and Therapeutic Medicine, 2010
Estimation of the postmortem interval (PMI) is one of the most important tasks in forensic medicine. Numerous methods have been proposed for the determination of the time since death by chemical means. High mobility group box-1 (HMGB1), a nonhistone DNA-binding protein is released by eukaryotic cells upon necrosis.
Kiyoshi, Kikuchi, Ko-Ichi, Kawahara, Kamal Krishna, Biswas, Takashi, Ito, Salunya, Tancharoen, Naoto, Shiomi, Yoshiro, Koda, Fumiyo, Matsuda, Yoko, Morimoto, Yoko, Oyama, Kazunori, Takenouchi, Naoki, Miura, Noboru, Arimura, Yuko, Nawa, Shinichiro, Arimura, Meng Xiao, Jie, Binita, Shrestha, Masahiro, Iwata, Kentaro, Mera, Hisayo, Sameshima, Yoshiko, Ohno, Ryuichi, Maenosono, Yutaka, Tajima, Hisaaki, Uchikado, Terukazu, Kuramoto, Kenji, Nakayama, Minoru, Shigemori, Yoshihiro, Yoshida, Teruto, Hashiguchi, Ikuro, Maruyama   +29 more
openaire   +3 more sources

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease. [PDF]

, 2019
The maintenance of genomic integrity is essential for normal cellular functions. However, it is difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA damage increases with age and is exacerbated by multiple neurological
Adame, Anthony, Evans, Mark D, Mao, Wenjie, Masliah, Eliezer, Mucke, Lennart, Nana, Alissa L, Rissman, Robert A, Seeley, William W, Shanbhag, Niraj M   +8 more
core   +2 more sources