Results 61 to 70 of about 33,001 (257)

Detection of H3K4me3 Identifies NeuroHIV Signatures, Genomic Effects of Methamphetamine and Addiction Pathways in Postmortem HIV+ Brain Specimens that Are Not Amenable to Transcriptome Analysis

Viruses, 2021
Human postmortem specimens are extremely valuable resources for investigating translational hypotheses. Tissue repositories collect clinically assessed specimens from people with and without HIV, including age, viral load, treatments, substance use ...
Liana Basova, Alexander Lindsey, Anne Marie McGovern, Ronald J. Ellis, Maria Cecilia Garibaldi Marcondes   +4 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Comparison of Biochemical versus Morphological Changes of Human In-Vitro Stored and Postmortem Blood Specimens during Different Time Intervals [PDF]

Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2014
Objectives: Estimation of post mortem interval (PMI) remains one of the most difficult challenges to a medicolegal expert. Postmortem biochemical changes may provide chemical markers to help more accurate determination of the postmortem interval ...
Mohamad Hosam El-Din, Heba Mostafa, Eman Alaa El-Din   +2 more
doaj   +1 more source

Postmortem Interval and Diagnostic Performance of the Autopsy Methods [PDF]

Scientific Reports, 2018
AbstractPostmortem studies, including the complete diagnostic autopsy (CDA) and the minimally invasive autopsy (MIA), an innovative approach to post-mortem sampling and cause of death investigation, are commonly performed within 24 hours after death because the quality of the tissues deteriorates over time.
Juan Carlos Hurtado, Llorenç Quintó, Paola Castillo, Carla Carrilho, Fabíola Fernandes, Dércio Jordão, Lucília Lovane, Mireia Navarro, Irene Casas, Rosa Bene, Tacilta Nhampossa, Paula Santos Ritchie, Sónia Bandeira, Calvino Sambo, Valéria Chicamba, Sibone Mocumbi, Zara Jaze, Flora Mabota, Mamudo R. Ismail, Cesaltina Lorenzoni, Assucena Guisseve, Natalia Rakislova, Lorena Marimón, Natalia Castrejón de Anta, Ariadna Sanz, Anélsio Cossa, Inácio Mandomando, Khátia Munguambe, María Maixenchs, Carmen Muñoz-Almagro, Eusébio Macete, Pedro L. Alonso, Jordi Vilà, Quique Bassat, Clara Menéndez, Miguel J. Martínez, Jaume Ordï   +36 more
openaire   +4 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

HMGB1: A new marker for estimation of the postmortem interval

Experimental and Therapeutic Medicine, 2010
Estimation of the postmortem interval (PMI) is one of the most important tasks in forensic medicine. Numerous methods have been proposed for the determination of the time since death by chemical means. High mobility group box-1 (HMGB1), a nonhistone DNA-binding protein is released by eukaryotic cells upon necrosis.
Kiyoshi, Kikuchi, Ko-Ichi, Kawahara, Kamal Krishna, Biswas, Takashi, Ito, Salunya, Tancharoen, Naoto, Shiomi, Yoshiro, Koda, Fumiyo, Matsuda, Yoko, Morimoto, Yoko, Oyama, Kazunori, Takenouchi, Naoki, Miura, Noboru, Arimura, Yuko, Nawa, Shinichiro, Arimura, Meng Xiao, Jie, Binita, Shrestha, Masahiro, Iwata, Kentaro, Mera, Hisayo, Sameshima, Yoshiko, Ohno, Ryuichi, Maenosono, Yutaka, Tajima, Hisaaki, Uchikado, Terukazu, Kuramoto, Kenji, Nakayama, Minoru, Shigemori, Yoshihiro, Yoshida, Teruto, Hashiguchi, Ikuro, Maruyama   +29 more
openaire   +3 more sources