Results 41 to 50 of about 32,960 (259)

Post-mortem interval of buried homicides in Okuku, Nigeria

Egyptian Journal of Forensic Sciences, 2023
Background Post-mortem interval estimation of carcasses buried in shallow graves is a grey area in Nigerian forensic investigations. Most of the investigations and court decisions on the time of death of concealed homicides are based on assumptions in ...
Darlington Nnamdi Onyejike, Victor Adolf Fischer, Ugochukwu Godfrey Esomonu, Ifeoma Miracle Onyejike   +3 more
doaj   +1 more source

Effects of Postmortem Interval on Biomolecule Integrity in the Brain [PDF]

Journal of Neuropathology & Experimental Neurology, 2015
Postmortem brain research is invaluable to the study of neurologic and neuropsychiatric disorders, including Alzheimer disease, schizophrenia, and major depression. A major confounder in molecular studies using human brain tissue is postmortem interval (i.e. the amount of time between a subject's death and processing of tissue).
Corina, Nagy, Marissa, Maheu, Juan Pablo, Lopez, Kathryn, Vaillancourt, Cristiana, Cruceanu, Jeffrey A, Gross, Mitchell, Arnovitz, Naguib, Mechawar, Gustavo, Turecki   +8 more
openaire   +2 more sources

Estimation of Early Postmortem Interval from Long Noncoding RNA Gene Expression in the Incised Cutaneous Wound: An Experimental Study

Biomedicines, 2022
The assessment of alteration of postmortem RNA expression has forensic significance in estimating postmortem interval. To evaluate wound healing progression and the effect of different postmortem intervals, histopathological changes, immunohistochemical ...
Mona M. Ali, Samah F. Ibrahim, Noha M. Elrewieny, Aya M. Elyamany, Wagdy K. B. Khalil, Aziza B. Shalby, Sarah A. Khater   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Estimation of the postmortem interval by non-linear programming in conditions of changing ambient temperature

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
The aim of the study is to evaluate the possibilities of determining the postmortem interval by non-linear programming in conditions of changing ambient temperature.
G. V. Nedugov
doaj   +1 more source

PERBANDINGAN GAMBARAN HISTOPATOLOGI OTAK TIKUS WISTAR YANG DIGANTUNG DENGAN PEMBEDAAN PERIODE POSTMORTEM

Jurnal Kedokteran Diponegoro, 2019
Latar Belakang: Penggantungan adalah kematian akibat asfiksia yang paling sering ditemukan. Penggantungan dapat dilakukan antemortem (saat korban masih hidup) dan postmortem (saat korban sudah meninggal).
Rr Hillary Kusharsamita, Intarniati Nur Rohmah, Ika Pawitra Miranti   +2 more
doaj   +1 more source

Research Progress on Postmortem Interval Estimation by Vitreous Humor [PDF]

Fayixue Zazhi, 2018
Postmortem interval （PMI） estimation is one of the most challenging problems in the field of forensic science. Vitreous humor is a hotspot which has been used for PMI estimation and postmortem chemical analysis in forensic pathology.
YANG Ming-zhen, ZHANG Tian-ye, LI Hui-jun，et al
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Detection of H3K4me3 Identifies NeuroHIV Signatures, Genomic Effects of Methamphetamine and Addiction Pathways in Postmortem HIV+ Brain Specimens that Are Not Amenable to Transcriptome Analysis

Viruses, 2021
Human postmortem specimens are extremely valuable resources for investigating translational hypotheses. Tissue repositories collect clinically assessed specimens from people with and without HIV, including age, viral load, treatments, substance use ...
Liana Basova, Alexander Lindsey, Anne Marie McGovern, Ronald J. Ellis, Maria Cecilia Garibaldi Marcondes   +4 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source