Results 71 to 80 of about 1,389,416 (314)

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Survival after postoperative morbidity: a longitudinal observational cohort study. [PDF]

, 2014
BACKGROUND: Previous studies have suggested that there may be long-term harm associated with postoperative complications. Uncertainty exists however, because of the need for risk adjustment and inconsistent definitions of postoperative morbidity. METHODS:
Harris, S, Rowan, KM, Moonesinghe, S.R., Emberton, M., Harris, S., Haddad, FS, Mythen, MG, Haddad, F.S., Moonesinghe, SR, Emberton, M, Grocott, MP, Grocott, M.P.W., Rowan, K.M., Grocott, MPW, Mythen, M.G.   +14 more
core   +1 more source

Complementing Engel Classification: Postoperative Scalp EEG as an Objective Indicator in SEEG‐Guided Radiofrequency Thermocoagulation—A Seizure‐Onset Pattern‐Based Stratified Analysis—

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) is a minimally invasive therapy for drug‐resistant focal epilepsy. However, the relationship between specific seizure‐onset patterns (SOPs), particularly low‐voltage fast activity (LVFA), and postoperative scalp EEG normalization remains inadequately ...
Yi‐qing Yang, Rui Zhang, Haiyan Ma, Lu Yang, Xuefeng Qu, Qiqi Chen, Yan Zhang   +6 more
wiley   +1 more source

Rheumatoid Arthritis, Frailty, and Outcomes of Surgical Hospitalizations: A National Population‐Based Analysis

Arthritis Care &Research, EarlyView.
Objective Hospitalization, particularly for surgery, represents a period of heightened stress. We evaluated how frailty attenuates the association of rheumatoid arthritis (RA) with negative health outcomes after elective noncardiac surgery. Methods We conducted a cross‐sectional study using the National Inpatient Sample (2018 to 2020), including adults
Ali Yazdanyar, Joshua Baker, Katherine D. Wysham, Mohammed Yousufuddin, Farah Acher Kaiksow, Michael M. Ward   +5 more
wiley   +1 more source

The content and reporting completeness of physical therapist‐led interventions for glenohumeral osteoarthritis: a systematic review

Arthritis Care &Research, Accepted Article.
Objectives This study synthesised the content and reporting completeness of published physical therapist‐led interventions for glenohumeral osteoarthritis (GHOA). Methods This systematic review undertook electronic database searches in PubMed, EMBASE, Cochrane, CINAHL and PEDro (until June 2025) for any peer‐reviewed articles/studies describing ...
Daha G Muhammad, Nadine E Foster, Mickylle Pelaez, Karina O'Leary, Ilana N Ackerman, Jonathan G Quicke   +5 more
wiley   +1 more source

Bioinspired Hydrogels with Broadly Programmable Mechanics for Soft‐Tissue Interfaces

Advanced Functional Materials, EarlyView.
Sea cucumber‐inspired gelatin hydrogels are formed by directional freezing and mechanically programmed through subsequent ionic treatment. Multiscale characterization and modeling link ion‐regulated chain interactions to directional load transfer within the aligned hierarchical architecture.
Youchao Teng, TzuChun Chung, Katpady Akhil Tantry, Siyu Wu, Jing Tian, Yunqi Cui, Lanyu Li, Yongzan Zhou, Zhilei Zhang, Zhe Su, Gaili Cao, Kun‐Wei Yeh, Ruipeng Li, Xianghui Xiao, Adam F. G. Leontowich, Yuan‐Yu Hsueh, Zhao Pan, Kam C. Tam, Badri Narayanan, Song Li, Yimin. A. Wu   +20 more
wiley   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Efficacy of metoclopramide and dexamethasone for postoperative nausea and vomiting: a double-blind clinical trial [PDF]

Postoperative nausea and vomiting are common complications of anaesthesia. This double-blind clinical trial assessed the incidence of nausea and vomiting after cataract surgery with intravenous anaesthesia in 100 patients randomly assigned to ...
عیسی زاده فر, خاطره, اخوان اکبری, قدرت, انتظاری, مسعود, خوشباطن, منوچهر   +3 more
core   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Source, triggers and clinical implications of hyperlactemia in patients undergoing mitral valve surgery using Custodiol cardioplegia [PDF]

, 2013
Postoperative blood hyperlactaemia is an indicator of organ anaerobic metabolism and is associated with morbidity after cardiac surgery. This prospective study aims to explore the source, triggers and clinical implications for hyperlactaemia in patients ...
Zanchettin, Chiara, Angelini, Gianni D, Zoffoli, Giampaolo, Suleiman, M.Saadeh, Ascione, Raimondo, Polesel, Elvio, Mangino, Domenico, Venturini, Andrea   +7 more
core   +1 more source