Results 41 to 50 of about 661,738 (296)

POSTOPERATIVE ANALGESIA IN ORTHOPEDIC SURGERY

, 2022
Postoperative analgesia is an important part of the healing process. Adequate analgesia allows early mobilization, reducing complications such as thromboembolism and allowing patients to start their daily lives.
Öterkus, Mesut
core  

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Postoperative Analgesia after Total Knee Arthroplasty: a Comparative Analysis of Current Treatment Techniques Effectiveness

Travmatologiâ i Ortopediâ Rossii, 2019
The objective of the study was to evaluate the effectiveness and safety of high-volume local infiltration and epidural analgesic techniques after primary total knee arthroplasty versus standard systemic multimodal analgesia in the context of the ...
D. A. Tarasov, A. V. Lychagin, Ya. A. Rukin, V. A. Kozhevnikov, A. G. Yavorovskiy, A. V. Strokov   +5 more
doaj   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Preoperative coping strategies and distress predict postoperative pain and morphine consumption in women undergoing abdominal gynecologic surgery [PDF]

, 2005
Objectives The aim of the present study was to predict postoperative pain and morphine consumption based on preoperative psychosocial factors. Methods One hundred and twenty-two women completed measures of distress and coping 1 week before major ...
Fouladi, Rachel T., Katz, Joel, Cohen, Lorenzo   +2 more
core  

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

The effects of three different analgesia techniques on long-term postthoracotomy pain.

, 2002
In this clinical, randomized, prospective study, we compared the effects of three different analgesia techniques (thoracic epidural analgesia [TEA] with and without preoperative initiation and IV patient-controlled analgesia [IV-PCA]) on postthoracotomy ...
Ozcan, PE, Talu, GK, Senturk, M, Camci, E, Kiyan, ESEN, Ozyalcin, S, Pembeci, Kamil, Dilege, S   +7 more
core   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Postoperative opioid-free analgesia with acetaminophen and its impact on pain and postoperative nausea and vomiting following arthroscopic rotator cuff repair: a single-center retrospective study

Journal of Pharmaceutical Health Care and Sciences
Background Opioids are commonly used for postoperative analgesia after arthroscopic rotator cuff repair; however, they pose an increased risk of postoperative nausea and vomiting. Therefore, multimodal analgesia using non-opioid analgesics is recommended.
Misa Okizuka, Ryo Inose, Shiho Maruoka, Mikiko Takeuchi, Subaru Hirotsu, Miki Nakamura, Yuichi Muraki   +6 more
doaj   +1 more source

Effectiveness of the erector spinae plane block for analgesia in lung resection surgery: a prospective randomized controlled trial

Медицина неотложных состояний
Background. Lung resection procedures performed via a conventional thoracotomy are associated with substantial surgical trauma and pronounced postoperative pain.
A.P. Perkonos, I.I. Lisnyy
doaj   +1 more source