Results 71 to 80 of about 1,286,307 (364)

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

Animal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai, Xintao Zhang, Tingting Luo, Wenhan Chen, Chenyu Ma, Haihua Luo, Jinghua Liu, Jia Xu   +7 more
wiley   +1 more source

Comparison of intrathecal morphine versus erector spinae block for postoperative analgesia in patients with end-stage kidney disease undergoing kidney transplantation: A randomised clinical study

Indian Journal of Anaesthesia
Background and Aims: Intrathecal morphine (ITM) or erector spinae plane (ESP) block reduces postsurgical pain in patients who underwent kidney transplantation surgeries.
Saurabh Mittal, Medha Bhardwaj, Praveenkumar Shekhrajka, Vipin Kumar Goyal   +3 more
doaj   +1 more source

Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas

Annals of Neurology, EarlyView.
Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek, David F. Hanff, Pim J. French, Sarah A. van Dijk, Erik A.C. Wiemer, Olivier C. Manintveld, Martin J. van den Bent, Walter Taal   +7 more
wiley   +1 more source

Comparative study of caudal clonidine and midazolam added to bupivacaine during infra-umbilical surgeries in children

Journal of Anaesthesiology Clinical Pharmacology, 2017
Background and Aims: Caudal analgesia is a good, reliable, and easy method to provide intraoperative and postoperative analgesia for infra-umbilical surgeries in children.
Sadhana Sanwatsarkar, Sahil Kapur, Dipti Saxena, Gaurav Yadav, Nagina Naz Khan   +4 more
doaj   +1 more source

Ultrasound-Guided Lateral Femoral Cutaneous Nerve Cryoneurolysis for Analgesia in Patients With Burns. [PDF]

, 2020
Autologous skin grafting from the thigh is frequently required for treatment of burns and is associated with intense pain at the donor site. Local anesthetic-based (LA) nerve blocks of the lateral femoral cutaneous nerve (LFCN) have been demonstrated to ...
Fiallo, Alfredo, Finneran, John J, Gabriel, Rodney A, Hamilton, Jeffrey R, Ilfeld, Brian M, Lee, Jeanne G, Swisher, Matthew W   +6 more
core  

Antibacterial Applications of Black and Violet Phosphorus‐Based Biomaterials

Advanced NanoBiomed Research, EarlyView.
Black and violet phosphorus‐based biomaterials exhibit broad‐spectrum antibacterial efficacy in various infections, including bone, skin, ocular, dental, lung, and sepsis cases. Their antibacterial mechanisms include physical disruption, light‐driven effects, targeted drug delivery, and enhanced composite strategies.
Zhuo Dai, Yu Zhang, Xiaoye Li, Ao He, Qiang Li, Weijun Xiu, Yongbin Mou, Heng Dong, Meng Ding   +8 more
wiley   +1 more source

A comparison of femoral/sciatic nerve block with lateral femoral cutaneous nerve block and combined spinal epidural anesthesia for total knee replacement arthroplasty [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundSeveral factors, such as compromised cardiopulmonary function, anticoagulative therapy, or anatomical deformity in the elderly, prevent general anesthesia and neuraxial blockade from being conducted for total knee replacement arthroplasty (TKRA)
Jong Hae Kim, Myoung Rae Cho, Si Oh Kim, Jung Eun Kim, Dong Keun Lee, Woon Seok Roh   +5 more
doaj   +1 more source

Suture-method versus Through-the-needle Catheters for Continuous Popliteal-sciatic Nerve Blocks: A Randomized Clinical Trial. [PDF]

, 2020
BACKGROUND:The basic perineural catheter design has changed minimally since inception, with the catheter introduced through or over a straight needle. The U.S.
Abanobi, Maryann U, Abramson, Wendy B, Dalstrom, David J, Finneran, John J, Gabriel, Rodney A, Ilfeld, Brian M, Kent, William T, Mascha, Edward J, Said, Engy T, Schwartz, Alexandra K, Swisher, Matthew W, Yang, Dongsheng   +11 more
core  

The persistence of chronic opioid use in patients with inflammatory bowel disease—A nationwide cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pain is common in patients with Crohn's disease (CD) and ulcerative colitis (UC), and a substantial proportion develop chronic opioid use (COU). We examined the persistence of COU over time and identified factors predicting persistent use. Methods This nationwide Danish cohort study included patients with an initial period of COU (definition: ≥3 ...
Bente Mertz Nørgård, Caroline Theilgaard Thorarinsson, Jan Nielsen, Mette Louise Andersen, Jens Kjeldsen, Torben Knudsen, Rahul S. Dalal   +6 more
wiley   +1 more source

90% minimum effective concentration of ropivacaine for ultrasound-guided supra-inguinal fascia Iliaca compartment block for postoperative analgesia following total hip arthroplasty: a dose-finding study

BMC Anesthesiology
Background The ultrasound-guided supra-inguinal fascia iliaca compartment block (S-FICB) is a widely utilized regional anesthesia technique for postoperative pain management following total hip arthroplasty.
Yanping Zhang, Qin Zhang, Bo Guo, Liang Zhang   +3 more
doaj   +1 more source