Postsynaptic current bursts instruct action potential firing at a graded synapse. [PDF]
Nat Commun, 2013 Nematode neurons generally produce graded potentials instead of action potentials. It is unclear how the graded potentials control postsynaptic cells under physiological conditions. Here we show that postsynaptic currents frequently occur in bursts at the neuromuscular junction of Caenorhabditis elegans.
Liu P, Chen B, Wang ZW.
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Estimating Transmitter Release Rates from Postsynaptic Current Fluctuations [PDF]
The Journal of Neuroscience, 2001 A method is presented that allows one to estimate transmitter release rates from fluctuations of postsynaptic current records under conditions of stationary or slowly varying release. For experimental applications, we used the calyx of Held, a glutamatergic synapse, in which “residual current,” i.e., current attributable to residual glutamate in the ...
Erwin Neher, Takeshi Sakaba
semanticscholar +7 more sources
GABAB Receptors Augment TRPC3-Mediated Slow Excitatory Postsynaptic Current to Regulate Cerebellar Purkinje Neuron Response to Type-1 Metabotropic Glutamate Receptor Activation. [PDF]
Cells, 2018 During strong parallel fiber stimulation, glutamate released at parallel fiber-Purkinje cell synapses activates type-1 metabotropic glutamate receptor (mGluR1) to trigger a slow excitatory postsynaptic current (sEPSC) in cerebellar Purkinje neurons.
Tian J, Zhu MX.
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Tetanically induced LTP involves a similar increase in the AMPA and NMDA receptor components of the excitatory postsynaptic current: investigations of the involvement of mGlu receptors [PDF]
Journal of Neuroscience, 1995 Whole-cell patch-clamp recordings of evoked excitatory postsynaptic currents (EPSCs) were made from granule cells of the rat dentate gyrus in vitro. Tetanic stimulation in control media evoked a statistically identical long-term potentiation (LTP) of ...
John O’Connor, MJ Rowan, Roger Anwyl
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Synchronized bursts of miniature inhibitory postsynaptic currents
The Journal of Physiology, 2010 Spike-independent miniature postsynaptic currents are generally stochastic and are therefore not thought to mediate information relay in neuronal circuits. However, we recorded endogenous bursts of IPSCs in hypothalamic magnocellular neurones in the presence of TTX, which implicated a coordinated mechanism of spike-independent GABA release. IPSC bursts
I. Popescu +5 more
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Vesicular Release Statistics and Unitary Postsynaptic Current at Single GABAergic Synapses [PDF]
Neuron, 2015 The existence of vesicular docking sites in central synapses is supported by morphological and biochemical evidence, but their functional role remains elusive. To investigate this role we have studied single depressing GABAergic synapses where multivesicular release and postsynaptic receptor saturation have been documented.
Camila Pulido +3 more
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Characterisation of inhibitory and excitatory postsynaptic currents of the rat medial superior olive [PDF]
The Journal of Physiology, 2000 The medial superior olive (MSO) is part of the binaural auditory pathway, receiving excitatory projections from both cochlear nuclei and an inhibitory input from the ipsilateral medial nucleus of the trapezoid body (MNTB). We characterised the excitatory and inhibitory synaptic currents of MSO neurones in 3- to 14-day-old rats using whole-cell patch ...
Amanda Smith +2 more
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Differential Effects of Alpha 1-Adrenoceptor Antagonists on the Postsynaptic Sensitivity: Using Slice Patch-Clamp Technique for Inhibitory Postsynaptic Current in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats. [PDF]
Int Neurourol J, 2020 Uta D, Hattori T, Yoshimura M.
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Vesicular Dopamine Release Elicits an Inhibitory Postsynaptic Current in Midbrain Dopamine Neurons [PDF]
Neuron, 2004 Michael J. Beckstead +3 more
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Analysis of fast excitatory postsynaptic currents in bullfrog parasympathetic ganglion cells [PDF]
The Journal of Neuroscience, 1983 Excitatory postsynaptic currents (EPSCs), miniature excitatory postsynaptic currents (MEPSCs), and acetylcholine-induced current fluctuations (noise) have been studied in voltage-clamped bullfrog parasympathetic ganglion cells of the atrial septum. EPSCs were also recorded from voltage-clamped sympathetic B cells and, in general, it was found that the ...
EA Connor, RL Parsons
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