Results 1 to 10 of about 142,409 (303)

Acute application of Centella asiatica extract enhanced AMPAR-mediated postsynaptic currents in rat entorhinal cortex [PDF]

open access: yesJournal of Integrative Neuroscience, 2020
Centella asiatica is notable for its wide range of biological activities beneficial to human health, particularly its cognitive enhancement and neuroprotective effects.
Jia Hui Wong, Faruque Reza, Sangu Muthuraju, Huei Gau Chuang, Jingli Zhang, Mohd Harizal Senik, Siti Rafidah Yusof, Habsah Mohamad, Tengku Sifzizul Tengku Muhammad, Nor Hadiani Ismail, Jafri Malin Abdullah
doaj   +1 more source

Imperfect space clamp permits electrotonic interactions between inhibitory and excitatory synaptic conductances, distorting voltage clamp recordings. [PDF]

open access: yesPLoS ONE, 2011
The voltage clamp technique is frequently used to examine the strength and composition of synaptic input to neurons. Even accounting for imperfect voltage control of the entire cell membrane ("space clamp"), it is often assumed that currents measured at ...
Alon Poleg-Polsky, Jeffrey S Diamond
doaj   +1 more source

Transcranial focused ultrasound induces sustained synaptic plasticity in rat hippocampus

open access: yesBrain Stimulation, 2022
Transcranial focused ultrasound (tFUS) neuromodulation provides a promising emerging non-invasive therapy for the treatment of neurological disorders.
Xiaodan Niu, Kai Yu, Bin He
doaj   +1 more source

Efavirenz restored NMDA receptor dysfunction and inhibited epileptic seizures in GluN2A/Grin2a mutant mice

open access: yesFrontiers in Neuroscience, 2023
IntroductionN-methyl-D-aspartate receptor (NMDAR) is one of the main receptor of the excitatory neurotransmitter glutamate in the brain, which is the key determinant of the excitatory/inhibitory balance of neural network.
Teng Zhao   +7 more
doaj   +1 more source

Probabilistic Fluorescence-Based Synapse Detection [PDF]

open access: yes, 2016
Brain function results from communication between neurons connected by complex synaptic networks. Synapses are themselves highly complex and diverse signaling machines, containing protein products of hundreds of different genes, some in hundreds of ...
Aguerrebere, Cecilia   +7 more
core   +8 more sources

The positive allosteric modulator of NMDA receptors, GNE‐9278, blocks the ethanol‐induced decrease of excitability in developing retrosplenial cortex neurons from mice

open access: yesNeuropsychopharmacology Reports, 2023
Binge‐like exposure to ethanol during the brain growth spurt triggers apoptotic neurodegeneration in multiple brain regions, including the retrosplenial cortex, a brain region that is part of the hippocampal‐diencephalic‐cingulate memory network. This is
Clark W. Bird, Carlos F. Valenzuela
doaj   +1 more source

Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex

open access: yeseLife, 2020
In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum.
Andreas Hoehne   +2 more
doaj   +1 more source

Hyperpolarization following activation of K+ channels by excitatory postsynaptic potentials [PDF]

open access: yesNature, 1983
We have postulated that an excitatory postsynaptic potential (e.p.s.p.) may open voltage-sensitive K+ ('M') channels, in an appropriate depolarizing range, and that this could alter the e.p.s.p. waveform. Consequently, the fast e.p.s.p. in neurones of sympathetic ganglia, elicited by a nicotinic action of acetylcholine (ACh), could be followed by a ...
Tosaka, Tsuneo   +3 more
openaire   +2 more sources

The Yin and Yang of GABAergic and Glutamatergic Synaptic Plasticity: Opposites in Balance by Crosstalking Mechanisms

open access: yesFrontiers in Synaptic Neuroscience, 2022
Synaptic plasticity is a critical process that regulates neuronal activity by allowing neurons to adjust their synaptic strength in response to changes in activity.
Caitlyn A. Chapman   +2 more
doaj   +1 more source

Interferon-γ facilitates the synaptic transmission between primary afferent C-fibres and lamina I neurons in the rat spinal dorsal horn via microglia activation

open access: yesMolecular Pain, 2020
Recent studies have demonstrated an important role of the pro-inflammatory cytokine interferon-γ in neuropathic pain. Interferon-γ is upregulated in the lumbar spinal cord of nerve-injured rodents and intrathecal injection of interferon-γ has been shown ...
Gerda Reischer   +2 more
doaj   +1 more source

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