Results 31 to 40 of about 9,081,085 (259)

Dynamic matching of the excitatory and inhibitory postsynaptic LTD/LTP thresholds.

open access: yes, 2022
A. Plasticity curves of E-to-E (, blue) and I-to-E (, red) weights as a function of the postsynaptic rate νE with static, non-identical LTD/LTP thresholds (, ). B.
Julijana Gjorgjieva (255641)   +1 more
core   +1 more source

Functional maps of neocortical local circuitry

open access: yesFrontiers in Neuroscience, 2007
This review aims to summarize data obtained with different techniques to provide a functional map of the local circuit connections made by neocortical neurones, a reference for those interested in cortical circuitry and the numerical information required
Alex M Thomson, Christophe Lamy
doaj   +1 more source

Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus

open access: yesMolecular Brain, 2020
The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for axon guidance during development and are expressed by neurons in the mature brain.
Stephen D. Glasgow   +6 more
doaj   +1 more source

Underlying mechanisms of long-term potentiation during the inhibition of the cannabinoid CB1 and GABAB receptors in the dentate gyrus of hippocampus

open access: yesBMC Neuroscience, 2023
Background The release of various neurotransmitters and thereby the excitability of neuronal circuits are regulated by the endocannabinoid system in an activity-dependent manner. Hippocampal long-term potentiation (LTP) is augmented in cannabinoid type 1
Masoumeh Nazari   +4 more
doaj   +1 more source

Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis

open access: yesJournal of Biomedical Science, 2017
Alteration in the excitatory/inhibitory neuronal balance is believed to be the underlying mechanism of epileptogenesis. Based on this theory, GABAergic interneurons are regarded as the primary inhibitory neurons, whose failure of action permits ...
Hui Ye, Stephanie Kaszuba
doaj   +1 more source

Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury

open access: yesNeurobiology of Disease, 2020
Long-term consequences of status epilepticus (SE) occur in a significant proportion of those who survive the acute episode. We developed an in vivo model of acute focal neocortical SE (FSE) to study long-term effects on local cortical structure and ...
Maria-Belen Perez-Ramirez   +2 more
doaj   +1 more source

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

open access: yesFrontiers in Molecular Neuroscience, 2022
GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann   +6 more
doaj   +1 more source

Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus

open access: yesNeurobiology of Disease, 2013
After 1 h of lithium-pilocarpine status epilepticus (SE), immunocytochemical labeling of NMDA receptor NR1 subunits reveals relocation of subunits from the interior to the cell surface of dentate gyrus granule cells and CA3 pyramidal cells ...
David E. Naylor   +3 more
doaj   +1 more source

Emergence of beta/gamma oscillations: ING, PING, and what about RING? [PDF]

open access: yes, 2011
Poster presentation from Twentieth Annual Computational Neuroscience Meeting: CNS*2011 Stockholm, Sweden. 23-28 July 2011. Background: Oscillatory activity in high-beta and gamma bands (20-80Hz) is known to play an important role in cortical processing ...
Moca, Vasile V.   +5 more
core   +1 more source

Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders

open access: yes, 2022
Depressive disorders (DDs) are an increasingly common health problem that affects all age groups. DDs pathogenesis is multifactorial. However, it was proven that stress is one of the most important environmental factors contributing to the development of
Czechowska, Ewelina   +7 more
core   +1 more source

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