Results 21 to 30 of about 142,409 (303)

Phenomenological incorporation of nonlinear dendritic integration using integrate-and-fire neuronal frameworks. [PDF]

PLoS ONE, 2013
It has been discovered recently in experiments that the dendritic integration of excitatory glutamatergic inputs and inhibitory GABAergic inputs in hippocampus CA1 pyramidal neurons obeys a simple arithmetic rule as V(S)(Exp) ≈ V(E)(Exp) + V(I)(Exp) + kV(
Douglas Zhou, Songting Li, Xiao-hui Zhang, David Cai   +3 more
doaj   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source

Brain injury impairs working memory and prefrontal circuit function

Frontiers in Neurology, 2015
More than 2.5 million Americans suffer a traumatic brain injury (TBI) each year. Even mild to moderate traumatic brain injury causes long-lasting neurological effects.
Colin James Smith, Colin James Smith, Guoxiang eXiong, Jaclynn eElkind, Brendan James Putnam, Akiva eCohen   +5 more
doaj   +1 more source

Effects of matrix metalloproteinase inhibitors on N-methyl-D-aspartate receptor and contribute to long-term potentiation in the anterior cingulate cortex of adult mice

Molecular Pain, 2019
Matrix metalloproteinases (MMPs) have been suggested to contribute to long-term potentiation, behavioral learning, and memory. In the dorsal horn of spinal cord, MMPs were reported to contribute to injury-related changes, and inhibitors of MMPs have been
Takanori Matsuura, Xu-Hui Li, Chen Tao, Min Zhuo   +3 more
doaj   +1 more source

A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum

Molecular Autism, 2020
Background DLG2, also known as postsynaptic density protein-93 (PSD-93) or chapsyn-110, is an excitatory postsynaptic scaffolding protein that interacts with synaptic surface receptors and signaling molecules.
Taesun Yoo, Sun-Gyun Kim, Soo Hyun Yang, Hyun Kim, Eunjoon Kim, Soo Young Kim   +5 more
doaj   +1 more source

The Mammalian Interaural Time Difference Detection Circuit Is Differentially Controlled by GABAB Receptors during Development [PDF]

, 2010
Throughout development GABAB receptors (GABABRs) are widely expressed in the mammalian brain. In mature auditory brainstem neurons, GABABRs are involved in the short-term regulation of the strength and dynamics of excitatory and inhibitory inputs, thus ...
Grothe, Benedikt, Hassfurth, Benjamin, Koch, Ursula   +2 more
core   +1 more source

γ-Hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices

European Journal of Pharmacology, 1999
Gamma-Hydroxybutyrate (GHB) has been shown to mimic different central actions of ethanol, to suppress alcohol withdrawal syndrome, and to reduce alcohol consumption both in rats and in humans. The aim of the present study was to determine if GHB shared with alcohol the ability to inhibit glutamate action at both NMDA and AMPA/kainate receptors.
BERTON, FULVIA, BRANCUCCI A, BEGHE' F, CAMMALLERI, MAURIZIO, DEMURO A, FRANCESCONI, WALTER, GESSA GL   +6 more
openaire   +4 more sources

Active summation of excitatory postsynaptic potentials in hippocampal CA3 pyramidal neurons [PDF]

Proceedings of the National Academy of Sciences, 1998
The manner in which the thousands of synaptic inputs received by a pyramidal neuron are summed is critical both to our understanding of the computations that may be performed by single neurons and of the codes used by neurons to transmit information. Recent work on pyramidal cell dendrites has shown that subthreshold synaptic inputs are modulated by ...
N N, Urban, G, Barrionuevo
openaire   +2 more sources

Aberrant excitatory rewiring of layer V pyramidal neurons early after neocortical trauma

Neurobiology of Disease, 2016
Lesioned neuronal circuits form new functional connections after a traumatic brain injury (TBI). In humans and animal models, aberrant excitatory connections that form after TBI may contribute to the pathogenesis of post-traumatic epilepsy.
D. Koji Takahashi, Feng Gu, Isabel Parada, Shri Vyas, David A. Prince   +4 more
doaj   +1 more source

Functional maps of neocortical local circuitry

Frontiers in Neuroscience, 2007
This review aims to summarize data obtained with different techniques to provide a functional map of the local circuit connections made by neocortical neurones, a reference for those interested in cortical circuitry and the numerical information required
Alex M Thomson, Christophe Lamy
doaj   +1 more source