Results 101 to 110 of about 156,710 (324)

Synaptic Organizers in Alzheimer’s Disease: A Classification Based on Amyloid-β Sensitivity

Frontiers in Cellular Neuroscience, 2020
Synaptic pathology is one of the major hallmarks observed from the early stage of Alzheimer’s disease (AD), leading to cognitive and memory impairment characteristic of AD patients.
Alfred Kihoon Lee, Alfred Kihoon Lee, Husam Khaled, Husam Khaled, Nicolas Chofflet, Nicolas Chofflet, Hideto Takahashi, Hideto Takahashi, Hideto Takahashi, Hideto Takahashi, Hideto Takahashi   +10 more
doaj   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Exercise improves behavioral dysfunction and inhibits the spontaneous excitatory postsynaptic current of D2-medium spiny neurons. [PDF]

Front Aging Neurosci, 2022
Zhao G, Zhang D, Qiao D, Liu X.
europepmc   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Morphine Differentially Alters the Synaptic and Intrinsic Properties of D1R- and D2R-Expressing Medium Spiny Neurons in the Nucleus Accumbens

Frontiers in Synaptic Neuroscience, 2019
Exposure to opioids reshapes future reward and motivated behaviors partially by altering the functional output of medium spiny neurons (MSNs) in the nucleus accumbens shell.
Dillon S. McDevitt, Dillon S. McDevitt, Benjamin Jonik, Nicholas M. Graziane   +3 more
doaj   +1 more source

Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice. [PDF]

Mol Brain, 2021
Han DH, Hong I, Choi JE, Park P, Baek JY, Park H, Ide S, Mishina M, Ikeda K, Kaang BK.   +9 more
europepmc   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease

Neural Plasticity, 2016
Disruption of synaptic function at excitatory synapses is one of the earliest pathological changes seen in wide range of neurological diseases. The proper control of the segregation of neurotransmitter receptors at these synapses is directly correlated ...
Holly Stefen, Chanchanok Chaichim, John Power, Thomas Fath   +3 more
doaj   +1 more source

Adiponectin Knockout Mice Display Cognitive and Synaptic Deficits

Frontiers in Endocrinology, 2019
Adiponectin is an adipokine that has recently been under investigation for potential neuroprotective effects in various brain disorders including Alzheimer's disease, stroke, and depression.
Jenna Bloemer, Jenna Bloemer, Priyanka D. Pinky, Priyanka D. Pinky, Warren D. Smith, Warren D. Smith, Dwipayan Bhattacharya, Alisa Chauhan, Manoj Govindarajulu, Manoj Govindarajulu, Hao Hong, Hao Hong, Muralikrishnan Dhanasekaran, Muralikrishnan Dhanasekaran, Robert Judd, Rajesh H. Amin, Rajesh H. Amin, Miranda N. Reed, Miranda N. Reed, Vishnu Suppiramaniam, Vishnu Suppiramaniam   +20 more
doaj   +1 more source

Reviewer #2 (Public Review): Homeostatic Synaptic Plasticity of Miniature Excitatory Postsynaptic Currents in Mouse Cortical Cultures Requires Neuronal Rab3A

, 2023
Koesters Andrew G., Rich Mark M., Engisch Kathrin L.   +2 more
openalex   +1 more source