Results 121 to 130 of about 156,710 (324)

IGZO‐Based First Spike Timing Tactile Encoders and Coupling‐Enhanced Transistor Synapses for Efficient Spiking Neural Networks

Advanced Science, EarlyView.
Here, a bioinspired light‐accelerated neuromorphic system that seamlessly links tactile sensing, first‐spike‐timing (FST) encoding, and light–electric synaptic learning. Pressure stimuli trigger FST spikes in dual‐gate PDTFTs, while GaOx/IGZO hetero‐synapses exhibit enhanced memory under optical–electrical co‐activation, enabling spiking neural ...
Dan Cai, Jinyong Wang, Tianchen Zhao, Miao Shen, Yunbo Liu, Tieyi Zhang, Fangjie Zhang, Yang Wang, Yadong Jiang, Deen Gu   +9 more
wiley   +1 more source

Presynaptic long-term plasticity

Frontiers in Synaptic Neuroscience, 2013
Long-term synaptic plasticity is a major cellular substrate for learning, memory, and behavioral adaptation. Although early examples of long-term synaptic plasticity described a mechanism by which postsynaptic signal transduction was potentiated, it is ...
Ying eYang, Nicole eCalakos
doaj   +1 more source

eLife Assessment: Homeostatic Synaptic Plasticity of Miniature Excitatory Postsynaptic Currents in Mouse Cortical Cultures Requires Neuronal Rab3A

, 2023
Dion Dickman
openalex   +1 more source

Design and Implementation of BCM Rule Based on Spike-Timing Dependent Plasticity

, 2012
The Bienenstock-Cooper-Munro (BCM) and Spike Timing-Dependent Plasticity (STDP) rules are two experimentally verified form of synaptic plasticity where the alteration of synaptic weight depends upon the rate and the timing of pre- and post-synaptic ...
Abbott, Derek, Al-Sarawi, Said, Azghadi, Mostafa Rahimi, Iannella, Nicolangelo   +3 more
core   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Increased excitability of layer 5 neocortical pyramidal neurons and its contribution to seizure activity in Gabrg2 gene-deficient mice

iScience
Summary: Gabrg2fl/wtCre+ (CKO) mice are one of the models for studying “genetic epilepsy with febrile seizures plus (GEFS+).” A previous study revealed increased cortical excitability in CKO mice subjected to hyperthermia (CKO-heat mice), but the ...
Yangyang Sun, Zhuoqi Li, Baocong Yu, Chun Zhang, Lei Wang, Baorui Guo, Jiangwei Ding, Lifei Xiao, Peng Gao, Xinxiao Li, Tao Sun   +10 more
doaj   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Optoelectronic Mesoporous Titania Memristor with Light‐Modulation by Laser Pointer

Advanced Physics Research
Here, optoelectronic synaptic device based on thin film mesoporous titania (meso‐TiO2) is demonstrated as sensing active layer under illumination of low power laser pointers (532 nm or 632 nm), which could modulate weight change of input signal under the
Dhanashri Vittahl Desai, Gillhwan Kim, Eunsu Jang, Hyun Ho Lee   +3 more
doaj   +1 more source

Alteration of the fast excitatory postsynaptic current by barium in voltage‐clamped amphibian sympathetic ganglion cells [PDF]

, 1984
Elizabeth A. Connor, Rodney L. Parsons
openalex   +1 more source