Results 11 to 20 of about 154,053 (277)

Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands

Nature Communications, 2022
Extensive studies concluded that homophilic interactions between pre- and postsynaptic teneurins, evolutionarily conserved cell-adhesion molecules, encode the specificity of synaptic connections.
Xuchen Zhang, Pei-Yi Lin, Kif Liakath-Ali, Thomas C. Südhof   +3 more
doaj   +1 more source

Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors

Neurobiology of Disease, 2020
Mutations in synaptic NMDA receptors (NMDARs) are associated with epilepsy and neurodevelopmental disorders. The effects of several such mutations have been investigated in recombinantly-expressed NMDARs under conditions of steady-state activation.
Xiumin Chen, Angelo Keramidas, Robert J. Harvey, Joseph W. Lynch   +3 more
doaj   +1 more source

Variance analysis as a method to predict the locus of plasticity at populations of non-uniform synapses

Frontiers in Cellular Neuroscience, 2023
Our knowledge on synaptic transmission in the central nervous system has often been obtained by evoking synaptic responses to populations of synapses. Analysis of the variance in synaptic responses can be applied as a method to predict whether a change ...
Lucas B. Lumeij, Aile N. van Huijstee, Natalie L. M. Cappaert, Helmut W. Kessels   +3 more
doaj   +1 more source

Minhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic events

Molecular Brain, 2021
To understand the information encoded in a connection between the neurons, postsynaptic current (PSC) has been widely measured as a primary index of synaptic strength in the field of neurophysiology.
Yong Gyu Kim, Jae Jin Shin, Sang Jeong Kim   +2 more
doaj   +1 more source

NMDA Currents Modulate the Synaptic Input–Output Functions of Neurons in the Dorsal Nucleus of the Lateral Lemniscus in Mongolian Gerbils [PDF]

, 2011
Neurons in the dorsal nucleus of the lateral lemniscus (DNLL) receive excitatory and inhibitory inputs from the superior olivary complex (SOC) and convey GABAergic inhibition to the contralateral DNLL and the inferior colliculi.
Felmy, Felix, Grothe, Benedikt, Meyer, Elisabeth M. M., Porres, Christian P.   +3 more
core   +1 more source

Selectivity of Monaural Synaptic Inputs Underlying Binaural Auditory Information Integration in the Central Nucleus of Inferior Colliculus

Frontiers in Cellular Neuroscience, 2018
Neurons in the central nucleus of the inferior colliculus (ICC) receive ascending inputs from the ipsilateral and contralateral auditory pathway.
Jinxing Wei, Wen Zhong, Cuiyu Xiao, Yun Liu, Changbao Song, Zhongju Xiao   +5 more
doaj   +1 more source

NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups [PDF]

Open Biology, 2017
N-Methyl-d-aspartate receptors (NMDARs) play diverse roles in synaptic transmission, synaptic plasticity, neuronal development and neurological diseases.
Tomoko Oshima-Takago, Hideki Takago
doaj   +1 more source

Influence of Mpv17 on Hair-Cell Mitochondrial Homeostasis, Synapse Integrity, and Vulnerability to Damage in the Zebrafish Lateral Line

Frontiers in Cellular Neuroscience, 2021
Noise exposure is particularly stressful to hair-cell mitochondria, which must produce enough energy to meet high metabolic demands as well as regulate local intracellular Ca2+ concentrations.
Melanie Holmgren, Lavinia Sheets, Lavinia Sheets   +2 more
doaj   +1 more source

Enhancement of synchronization in a hybrid neural circuit by spike timing dependent plasticity [PDF]

, 2003
Synchronization of neural activity is fundamental for many functions of the brain. We demonstrate that spike-timing dependent plasticity (STDP) enhances synchronization (entrainment) in a hybrid circuit composed of a spike generator, a dynamic clamp ...
Abarbanel, Henry D I, Nowotny, Thomas, Rabinovich, Mikhail I, Selverston, Allan I, Zhigulin, Valentin P   +4 more
core   +2 more sources

Retrograde Synaptic Signaling Mediated by K+ Efflux through Postsynaptic NMDA Receptors

Cell Reports, 2013
Synaptic NMDA receptors (NMDARs) carry inward Ca2+ current responsible for postsynaptic signaling and plasticity in dendritic spines. Whether the concurrent K+ efflux through the same receptors into the synaptic cleft has a physiological role is not ...
Pei-Yu Shih, Leonid P. Savtchenko, Naomi Kamasawa, Yulia Dembitskaya, Thomas J. McHugh, Dmitri A. Rusakov, Ryuichi Shigemoto, Alexey Semyanov   +7 more
doaj   +1 more source