Phencyclidine (PCP) blocks glutamate‐activated postsynaptic currents [PDF]
Phencyclidine Glutamate receptor Locust Neuromuscular transmission Excitatory postsynaptic current Channel blacker
M. Idriss, Edson X. Albuquerque
openaire +2 more sources
Voltage sensitivity of NMDA-receptor mediated postsynaptic currents [PDF]
Patch-clamp techniques were used to record pharmacologically-isolated N-methyl-D-aspartate-mediated excitatory postsynaptic currents (NMDA-EPSCs) from dentate granule cells in thin rat hippocampal slices. Membrane voltage modulated these EPSCs in two ways.
Konnerth, A.+3 more
openaire +4 more sources
NMDA Currents Modulate the Synaptic Input–Output Functions of Neurons in the Dorsal Nucleus of the Lateral Lemniscus in Mongolian Gerbils [PDF]
Neurons in the dorsal nucleus of the lateral lemniscus (DNLL) receive excitatory and inhibitory inputs from the superior olivary complex (SOC) and convey GABAergic inhibition to the contralateral DNLL and the inferior colliculi.
Felmy, Felix+3 more
core +1 more source
Enhancement of synchronization in a hybrid neural circuit by spike timing dependent plasticity [PDF]
Synchronization of neural activity is fundamental for many functions of the brain. We demonstrate that spike-timing dependent plasticity (STDP) enhances synchronization (entrainment) in a hybrid circuit composed of a spike generator, a dynamic clamp ...
Abarbanel, Henry D I+4 more
core +2 more sources
Acid-Sensing Ion Channels Activated by Evoked Released Protons Modulate Synaptic Transmission at the Mouse Calyx of Held Synapse [PDF]
Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. We found that these channels can be activated in neurons of the medial nucleus of the trapezoid body (MNTB) of the auditory system in ...
Di Guilmi, Mariano Nicolás+3 more
core +1 more source
Impulsive SICNNs with chaotic postsynaptic currents
In the present study, we investigate the dynamics of shunting inhibitory cellular neural networks (SICNNs) with impulsive effects. We give a mathematical description of the chaos for the multidimensional dynamics of impulsive SICNNs, and prove its existence rigorously by taking advantage of the external inputs.
Fen, Mehmet Onur, Akhmet, Marat
openaire +4 more sources
Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer+60 more
core +1 more source
Agonist-Dependent Postsynaptic Effects of Opioids on Miniature Excitatory Postsynaptic Currents in Cultured Hippocampal Neurons [PDF]
Although chronic treatment with morphine is known to alter the function and morphology of excitatory synapses, the effects of other opioids on these synapses are not clear. Here we report distinct effects of several opioids (morphine, [d-ala2,me-phe4,gly5-ol]enkephalin (DAMGO), and etorphine) on miniature excitatory postsynaptic currents (mEPSCs) in ...
Ping-Yee Law+3 more
openaire +2 more sources
Mechanisms of synaptic depression at the hair cell ribbon synapse that support auditory nerve function [PDF]
Inner hair cells (IHCs) in the cochlea are the mammalian phono-receptors, transducing sound energy into graded changes in membrane potentials, the so called “receptor potentials.” Ribbon synapses between IHCs and auditory nerve neurons are responsible ...
Goutman, Juan Diego
core +1 more source
Effects of guanidine on synaptic transmission in the spinal cord of the frog [PDF]
The effects of guanidine on motoneurons of the isolated frog spinal cord were studied by adding the drug to the solution bathing the cord during intracellular recording. Guanidine (5·10–4 M) did not alter the membrane potential of motoneurons.
A. K�hner+19 more
core +1 more source