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Postsynaptic Currents Prior to Onset of Epileptiform Activity in Rat Microgyria
Journal of Neurophysiology, 2007Structural malformations of the cortex, arising as a result of genetic mutation or injury during development are associated with dyslexia, epilepsy, and other neurological deficits. We have used a rat model of a microgyral malformation to examine mechanisms of epileptogenesis.
Kimberle M. Jacobs, Andrea Zsombok
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Fast excitatory postsynaptic currents in neurons of the rabbit pelvic plexus
Autonomic Neuroscience, 2002Fast excitatory postsynaptic currents have been recorded at 23-27 degrees C from rabbit pelvic plexus neurons by a two-electrode voltage-clamp technique. The synaptic current decay was bi-exponential with the fast and slow components characterized at -50 mV by mean time constants of 4.0 +/- 0.3 and 21.9 +/- 2.8 ms (n = 11), respectively.
Andrei Yu Bobryshev, V. I. Skok
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Effects of fenamate on inhibitory postsynaptic currents in Purkinje’s cells
Bulletin of Experimental Biology and Medicine, 2008The effects of nonsteroid antiinflammatory drugs of the fenamate group (mefenamic and tolfenamic acids) on spontaneous miniature inhibitory postsynaptic currents in Purkinje's cells were studied in mouse cerebellar slices by the whole cell patch-clamp method.
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Excitatory and Inhibitory Postsynaptic Currents in a Rat Model of Epileptogenic Microgyria
Journal of Neurophysiology, 2005Developmental cortical malformations are common in patients with intractable epilepsy; however, mechanisms contributing to this epileptogenesis are currently poorly understood. We previously characterized hyperexcitability in a rat model that mimics the histopathology of human 4-layered microgyria.
David A. Prince, Kimberle M. Jacobs
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Variations in amplitude and time course of inhibitory postsynaptic currents
Journal of Neurophysiology, 1986In order to examine the relative contributions of changes in amplitude and time course to synaptic plasticity, variations in peak amplitude and time constant of decay have been analyzed from inhibitory postsynaptic currents (PSC) recorded in voltage-clamped Aplysia buccal ganglia neurons.
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Modelling action of ionic channel blockers on postsynaptic currents
Neurophysiology, 1990A mathematical model of the effects of open (ionic) channel blockers on generation of postsynaptic current at the neuromuscular junction is described. Quantitative aspects of simple blocking action are analyzed as well as criteria by which blockade of ionic channels may be discriminated from modification of their activation kinetics.
Lev G. Magazanik +3 more
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Neuroscience Letters, 1983
In opener muscle fibres of the crayfish claw excitatory postsynaptic currents activated by glutamate (1 . 10(-4)-5 . 10(-4) mol/l) were investigated by means of the noise analysis technique. For the apparent mean open time of glutamate-activated channels, tau noise = 1.15 ms +/- 0.16 (S.D., n = 24) resulted at membrane potentials between E = -60 mV and
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In opener muscle fibres of the crayfish claw excitatory postsynaptic currents activated by glutamate (1 . 10(-4)-5 . 10(-4) mol/l) were investigated by means of the noise analysis technique. For the apparent mean open time of glutamate-activated channels, tau noise = 1.15 ms +/- 0.16 (S.D., n = 24) resulted at membrane potentials between E = -60 mV and
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Journal of Neurophysiology, 2003
Within the rat paraventricular nucleus of the hypothalamus two types of neurons have been distinguished based on morphological appearance, i.e., parvocellular and magnocellular neurons. The parvocellular neurons play a key role in regulating the activity of the hypothalamo–pituitary–adrenal axis, which is activated, e.g., after stress exposure.
Verkuyl, M., Joëls, M.
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Within the rat paraventricular nucleus of the hypothalamus two types of neurons have been distinguished based on morphological appearance, i.e., parvocellular and magnocellular neurons. The parvocellular neurons play a key role in regulating the activity of the hypothalamo–pituitary–adrenal axis, which is activated, e.g., after stress exposure.
Verkuyl, M., Joëls, M.
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General Pharmacology: The Vascular System, 1982
1. Equations have been developed for a computer programmed calculation of synaptic current from synaptic potentials (epsps). 2. The method permits separation of presynaptic and postsynaptic effects in experiments involving drugs which affect synaptic transmission.
L. Fischer, Ernst Florey
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1. Equations have been developed for a computer programmed calculation of synaptic current from synaptic potentials (epsps). 2. The method permits separation of presynaptic and postsynaptic effects in experiments involving drugs which affect synaptic transmission.
L. Fischer, Ernst Florey
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Sets of synaptic currents paired by common presynaptic or postsynaptic neurons
Journal of Neurophysiology, 19891. In the buccal ganglia of Aplysia, presynaptic neurons B4 and B5 produce similar inhibitory postsynaptic currents (PSCs) in several postsynaptic follower cells. Previous work has shown that both duration and amplitude of these PSCs vary, that each parameter may be altered transiently by manipulating presynaptic activity, and that these variations ...
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