Results 31 to 40 of about 156,710 (324)

Modeling Calcium Dynamics and Inhibition Based Synaptic Plasticity in Dendritic Spines

Mathematical Modelling and Analysis, 2014
Inhibitory synapses through GABAergic channels not only change spine's calcium dynamics but also modulate postsynaptic current mediated through glutamate receptors.
Muhammad Dur-e-Ahmad
doaj   +1 more source

Neurotoxin A2NTX Blocks Fast Inhibitory and Excitatory Transmitter Release From Presynaptic Terminals

Journal of Pharmacological Sciences, 2012
Our recent study showed a possibility that newly developed A2 type botulinum toxin (A2NTX) inhibits both spontaneous and evoked transmitter release from inhibitory (glycinergic or GABAergic) and excitatory (glutamatergic) nerve terminals using rat spinal
Toshitaka Yamaga, Shuji Aou, Min-Chul Shin, Masahito Wakita, Norio Akaike   +4 more
doaj   +1 more source

The Diazoxide Derivative 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide Augments AMPA- and GABA-Mediated Synaptic Responses in Cultured Hippocampal Neurons

Neurobiology of Disease, 1998
The diazoxide derivative 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide (IDRA21) enhances memory and learning in rodents, most likely by potentiating AMPAergic synaptic activity.
Kelvin A. Yamada, Matthew W. Hill, Yuefei Hu, Douglas F. Covey   +3 more
doaj   +1 more source

Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. [PDF]

, 2014
Lrp4, the muscle receptor for neuronal Agrin, is expressed in the hippocampus and areas involved in cognition. The function of Lrp4 in the brain, however, is unknown, as Lrp4-/- mice fail to form neuromuscular synapses and die at birth.
Burden, Steven J, Froemke, Robert C, Gomez, Andrea M   +2 more
core   +1 more source

Maximum likelihood estimation of biophysical parameters of synaptic receptors from macroscopic currents

Frontiers in Cellular Neuroscience, 2014
Dendritic integration and neuronal firing patterns strongly depend on biophysical properties of synaptic ligand-gated channels. However, precise estimation of biophysical parameters of these channels in their intrinsic environment is complicated and ...
Andrey eStepanyuk, Andrey eStepanyuk, Anya eBorisyuk, Anya eBorisyuk, Pavel eBelan, Pavel eBelan   +5 more
doaj   +1 more source

Enhanced functional detection of synaptic calcium-permeable AMPA receptors using intracellular NASPM

eLife, 2023
Calcium-permeable AMPA-type glutamate receptors (CP-AMPARs) contribute to many forms of synaptic plasticity and pathology. They can be distinguished from GluA2-containing calcium-impermeable AMPARs by the inward rectification of their currents, which ...
Ian Coombs, Cécile Bats, Craig A Sexton, Dorota Studniarczyk, Stuart G Cull-Candy, Mark Farrant   +5 more
doaj   +1 more source

Effects of guanidine on synaptic transmission in the spinal cord of the frog [PDF]

, 1977
The effects of guanidine on motoneurons of the isolated frog spinal cord were studied by adding the drug to the solution bathing the cord during intracellular recording. Guanidine (5·10–4 M) did not alter the membrane potential of motoneurons.
A. K�hner, B. Katz, E. Gergens, E. H. Lambert, F. Colomo, F. H. Norris, H. Ter�v�inen, J. I. Simpson, K. Koizumi, K. Ricker, M. A. Kamenskaya, M. A. Kamenskaya, M. Otsuka, P. Grafe, R. C. Scaer, S. D. Erulkar, S. J. Oh, U. Sonnhof, U. Sonnhof, W. C. Wiederholt   +19 more
core   +1 more source

Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]

, 1982
The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Baranyi, Ben-Ari, Brismar, Brown, Buckle, Collins, Constanti, DiFrancesco, Dingemanse, Galvan, Galvan, Galvan, Gerrit Ten Bruggencate, Gilbey, Golenhofen, Halliwell, Heinemann, Jankowska, Jefferys, Kocsis, Lemeignan, Lipicky, Llinaś, Lundh, Martin Galvan, Matthews, McAfee, Mori, Neuman, Nicholson, Nicoll, Pelhate, Peter Grafe, Pichon, Scholfield, Scholfield, Schwartzkroin, Schwartzkroin, Sherratt, Shimahara, Spyker, Szente, Thesleff, Thompson, Ulbricht, von Haxthausen, Yanagisawa, Yeh   +47 more
core   +1 more source

GABAergic synaptic transmission regulates calcium influx during spike-timing dependent plasticity

Frontiers in Synaptic Neuroscience, 2010
Coincident pre- and postsynaptic activity of hippocampal neurons alters the strength of gamma-aminobutyric acid (GABAA)-mediated inhibition through a Ca2+-dependent regulation of cation-chloride cotransporters.
Trevor Balena, Brooke A Acton, Melanie A Woodin   +2 more
doaj   +1 more source

Artificial synapses with photoelectric plasticity and memory behaviors based on charge trapping memristive system

Materials & Design, 2020
Imitation of memory and learning behaviors of nervous system by nanoscale photoelectric devices is highly desirable for building neuromorphic systems or even artificial neural networks.
Zhiliang Chen, Yu Yu, Lufan Jin, Yifan Li, Qingyan Li, Tengteng Li, Yating Zhang, Haitao Dai, Jianquan Yao   +8 more
doaj   +1 more source