Results 121 to 130 of about 119,060 (284)

Spermidine Reproduces the Anti‐Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal‐Induced Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu W. Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source

Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects

, 2022
Ru Yang, Yun Gao, Hui Li, Wei Huang, Dezhen Tu, Mengnan Yang, Xingqian Liu, Jau‐Shyong Hong, Hui‐Ming Gao   +8 more
openalex   +1 more source

HLA‐DQA1*01:02 is associated with antibody multi‐reactivity with citrulline‐containing type II collagen epitopes while HLA‐DRB1*04:01 is associated with more private antibody reactivity with citrulline‐containing IgG epitopes in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Anti‐citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) can be promiscuous, with cross‐reactive binding to many antigens containing short motifs, or private with little cross‐reactivity. Also, ACPA reactivity patterns differ among RA patients, including for motif‐containing epitopes in important self‐antigens like collagen ...
S. Janna Bashar, Courtney B. Myhr, Adam H. Titi, Zihao Zheng, Miriam A. Shelef   +4 more
wiley   +1 more source

Posttranslational Modification of Intercellular Messenger Systems

Frontiers in Endocrinology, 2014
Sho eKakizawa, Hiroyuki eKaiya, Akiyoshi eTakahashi   +2 more
doaj   +1 more source

A guide to UFMylation, an emerging posttranslational modification. [PDF]

FEBS J, 2023
Millrine D, Peter JJ, Kulathu Y.
europepmc   +1 more source

Impact of anesthesia and storage on posttranslational modifications of cardiac myofilament proteins [PDF]

, 2015
Megan S. Utter, Chad M. Warren, R. John Solaro   +2 more
openalex   +1 more source

Multi‐Omics‐Driven Adaptive Management of Biological Invasions: Toward a Proactive, Predictive, and Integrative Framework

Biological Diversity, EarlyView.
A proactive, predictive, and integrative framework that integrates multi‐omics innovations with ecological modeling and big data analytics to guide adaptive interventions and governance in invasive species management. By integrating multi‐omics insights with advanced ecological modeling, remote sensing, artificial intelligence, and cross‐disciplinary ...
Aibin Zhan
wiley   +1 more source

Lactylation: The emerging frontier in post-translational modification

Frontiers in Genetics
Lactate, a metabolic byproduct, has gained recognition as a highly influential signaling molecule. Lactylation, an emerging form of post-translational modification derived from lactate, plays a crucial role in numerous cellular processes such as ...
Zhou Lu, Xueting Zheng, Mingsong Shi, Yuan Yin, Yuanyuan Liang, Zhiyan Zou, Chenghe Ding, Yuanjing He, Yan Zhou, Xiaoan Li, Xiaoan Li   +10 more
doaj   +1 more source

Posttranslational modification at the N terminus of the human adenovirus type 12 E1A 235R tumor antigen [PDF]

, 1986
L A Lucher, Karl H. Brackmann, Janey Symington, M Green   +3 more
openalex   +1 more source

Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)

Chemistry &Biodiversity, EarlyView.
Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Randa M. Bawadi, Ayah Y. Almasri, Marya A. Hamad, Nour A. Hussein, Salem R. Yasin, Abdulrahman M. Saleh   +8 more
wiley   +1 more source