Results 101 to 110 of about 941,378 (248)

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Effect of posttranslational modification on the Na+, K+ ATPase kinetics [PDF]

, 2015
The Na+, K+ ATPase is an essential membrane protein in eukaryotic cells, which transports Na+ out of the cell in exchange for K+ into the cell. For this transport it hydrolyses one molecule of ATP for each cycle.
Garcia, Alvaro
core  

Posttranslational Modification of Gluten Shapes TCR Usage in Celiac Disease

, 2011
Posttranslational modification of Ag is implicated in several autoimmune diseases. In celiac disease, a cereal gluten-induced enteropathy with several autoimmune features, T cell recognition of the gluten Ag is heavily dependent on the posttranslational ...
Kristin S. Gunnarsen, Geir-Åge Løset, Inger Sandlie, Shuo-Wang Qiao, Knut E. A. Lundin, Melinda Ráki, Ludvig M. Sollid   +6 more
core   +1 more source

From Enrichment to Insight: Leveraging Preparative cIEF Enrichments and Characterization to Support Data‐Driven Integration Practices for cIEF‐based Analytics

ELECTROPHORESIS, EarlyView.
Preparative cIEF enrichment enabled isolation of a low‐abundance, poorly resolved basic charge variant identified during routine cIEF analysis. Orthogonal characterization by peptide mapping and SCX‐UV–MS revealed incomplete N‐terminal pyroglutamate formation and Fc methionine oxidation.
Ramya Rao, Dominik Herrmann, Seamus Kelley, Victoria Cotham, Logan Figular, Youmi Moon, Deanna Di Grandi, Kathir Muthusamy, Yue Fu, Nisha Palackal, Shunhai Wang, Ning Li, Jennifer B. Nguyen, Michael P. Rosconi, Erica A. Pyles   +14 more
wiley   +1 more source

Posttranslational Modification of p53:Cooperative Integrators of Function

, 2009
The p53 protein is modified by as many as 50 individual posttranslational modifications. Many of these occur in response to genotoxic or nongenotoxic stresses and show interdependence, such that one or more modifications can nucleate subsequent events ...
Anderson, Carl W., Meek, David W.
core   +1 more source

Kv3.1 activation suppresses provoked and spontaneous seizures in a mouse Dravet syndrome model

Epilepsia, EarlyView.
Abstract Objective γ‐Aminobutyric acidergic (GABAergic) parvalbumin‐positive (PV+) interneurons are critical for maintaining cortical inhibitory tone, with their dysfunction predictably leading to epilepsy. Rapid PV+ interneuron firing is essential for their normal function and is maintained in part by potassium voltage‐gated channels.
Sheryl Anne D. Vermudez, Mustafa Q. Hameed, Yongho Choe, Gabrielle E. McGinty, Amanda M. Liebhardt, Rui Lin, Benjamin Hui, Yini Liang, David J. Arce, Henry H. C. Lee, Mustafa Sahin, Alexander Rotenberg   +11 more
wiley   +1 more source

Out with the old: Hsp90 finds amino acid residue more useful than co-chaperone protein

Microbial Cell, 2017
Redundant functions maintained from single to multi-cellular organisms have made Saccharomyces cere-visiae an important model for the analysis of con-served com-plex cellular processes. Yeast has been especially useful in understanding the regulation and
Abbey D. Zuehlke, Leonard Neckers
doaj   +1 more source

Screening and identification of novel peptides stimulating GLP‐1 secretion from plant proteins after simulated gastrointestinal digestion

Food Biomacromolecules, EarlyView.
Effects of digestive products of quinoa, oat, barley, and mungbean proteins on GLP‐1 secretion are investigated using STC‐1 cell and animal experiments, and novel GLP‐1 secretion‐stimulating peptides are successfully identified by column chromatography and LC–MS/MS.
Hongdong Song, Shaoxia Ren, Qiuyun Fu, Lei Xue, Kai Huang, Hongwei Cao, Zetang Zhang, Junhu Li, Xiao Guan   +8 more
wiley   +1 more source

Tyrosine Sulfation as a Protein Post-Translational Modification

Molecules, 2015
Integration of inorganic sulfate into biological molecules plays an important role in biological systems and is directly involved in the instigation of diseases.
Yuh-Shyong Yang, Chen-Chu Wang, Bo-Han Chen, You-Hua Hou, Kuo-Sheng Hung, Yi-Chih Mao   +5 more
doaj   +1 more source

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

, 2014
We report the identification and characterization of a five-carbon protein posttranslational modification (PTM) called lysine glutarylation (Kglu). This protein modification was detected by immunoblot and mass spectrometry (MS), and then comprehensively ...
Peterson, Brett S., Muehlbauer, Michael J, Huang, He, Muehlbauer, Michael J., McGuire, Peter J., Zhang, Yi, Zhao, Yingming, Xu, Guofeng, Ilkayeva, Olga R., Park, Jeongsoon, McGuire, Peter J, Anderson, Kristin A., Pletcher, Scott D., Backos, Donald S., Olsen, Christian A, Wagner, Gregory R, Hirschey, Matthew D, Lombard, David B, Dai, Lunzhi, Braulke, Thomas, Tan, Minjia, Olsen, Christian Adam, Anderson, Kristin A, Lombard, David B., Ro, Jennifer, Green, Michelle F., Madsen, Andreas S, Ilkayeva, Olga R, Chen, Yue, Mühlhausen, Chris, Green, Michelle F, Chhoy, Peter, Schmiesing, Jessica, Hirschey, Matthew D., Madsen, Andreas Stahl, Peterson, Brett S, Backos, Donald S, Xie, Zhongyu, Pletcher, Scott D, Peng, Chao, Wagner, Gregory R.   +40 more
core   +1 more source