Results 81 to 90 of about 941,378 (248)

Recent Development of Genetic Code Expansion for Posttranslational Modification Studies

Molecules, 2018
Nowadays advanced mass spectrometry techniques make the identification of protein posttranslational modifications (PTMs) much easier than ever before. A series of proteomic studies have demonstrated that large numbers of proteins in cells are modified by
Hao Chen, Sumana Venkat, Paige McGuire, Qinglei Gan, Chenguang Fan   +4 more
doaj   +1 more source

Autoreactivity Versus Autoimmunity: Characteristics of Autoantigen‐Specific CD4 T Cells in Rheumatoid Arthritis and Health

Arthritis &Rheumatology, EarlyView.
Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

Protein post-translational modification regulates HIV-1 latency

生物医学转化
AIDS is a disease named acquired immunodeficiency syndrome, which caused by the human immunodeficiency virus (HIV). HIV can be divided into HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is a global pandemic that has caused serious harm.
Wu Tong, Wang Tiantian, Deng Kai
doaj   +1 more source

Nuclear proteasomes carry a constitutive posttranslational modification which derails SDS-PAGE (but not CTAB-PAGE) [PDF]

, 2014
We report that subunits of human nuclear proteasomes carry a previously unrecognised, constitutive posttranslational modification. Subunits with this modification are not visualised by SDS-PAGE, which is used in almost all denaturing protein gel ...
Tzortzis, Konstantinos, Snijders, Ambrosius P, Pitcher, David S., Kleijnen, Maurits F, Rahemtulla, Amin, De Mattos-Shipley, Kate, Kleijnen, Maurits F., Flynn, Helen, Snijders, Ambrosius P., Wang, Ziming, Roberts, Irene, Goudevenou, Katerina, Karadimitris, Anastasios, Pitcher, David S, De Mattos-Shipley, Kate M J, Bohn, George, Goudevenoua, Katerina, Bohn, Georg   +17 more
core   +1 more source

PTMs in short intrinsically disordered regions.

, 2022
PTM, posttranslational modification. (XLS)
Maximilian T. Strauss (4450606), Brenda A. Schulman (7382420), Isabell Bludau (12551634), Ozge Karayel (12551640), Sander Willems (3385004), Maria C. Tanzer (9407229), Wen-Feng Zeng (1797613), Fynn M. Hansen (12551637), Matthias Mann (13750)   +8 more
core   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Artificial Intelligence Transforming Post-Translational Modification Research

Bioengineering
Post-Translational Modifications (PTMs) are covalent changes to amino acids that occur after protein synthesis, including covalent modifications on side chains and peptide backbones.
Doo Nam Kim, Tianzhixi Yin, Tong Zhang, Alexandria K. Im, John R. Cort, Jordan C. Rozum, David Pollock, Wei-Jun Qian, Song Feng   +8 more
doaj   +1 more source

Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition

, 2017
Cell surface innate immune receptors can directly detect a variety of extracellular pathogens to which cytoplasmic innate immune sensors are rarely exposed.
Le Son Tran, James E. Vince, Paul J. Baker, Dominic De Nardo, Fiona Moghaddas, Annabell Bachem, Richard L. Ferrero, Thomas Hayman, Tan Nguyen, Seth L. Masters, Sammy Bedoui, Hazel Tye   +11 more
core   +1 more source

Discovery and Validation of Methacryllysine Modification on Histone Proteins [PDF]

, 2020
In recent years, a variety of new posttranslational protein modifications occurring on histone proteins have been discovered. This includes lysine crotonylation, an enzymatically regulated epigenetic histone mark.
Delaney, Kyle Adam
core   +1 more source