Results 171 to 180 of about 120,482 (333)

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

Editorial: Waken the Silent Majority: Principles and Pathogenic Significance of Non-Acetyl Acylation and Other Understudied Post-Translational Modifications

Frontiers in Cell and Developmental Biology, 2022
Fangliang Zhang, Fangliang Zhang
doaj   +1 more source

Status of treatment strategies for Hutchinson-Gilford progeria syndrome with a focus on prelamin: A posttranslational modification. [PDF]

Basic Clin Pharmacol Toxicol, 2022
Chen X, Yao H, Andrés V, Bergo MO, Kashif M.   +4 more
europepmc   +1 more source

An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans [PDF]

, 2017
Abbey D. Zuehlke, Michael Reidy, Coney P. C. Lin, Paul LaPointe, Sarah Alsomairy, D. Joshua Lee, Génesis M. Rivera-Márquez, Kristin Beebe, Thomas L. Prince, Sunmin Lee, Jane B. Trepel, Wanping Xu, Jill L. Johnson, Daniel C. Masison, Len Neckers   +14 more
openalex   +1 more source

CysModDB: a comprehensive platform with the integration of manually curated resources and analysis tools for cysteine posttranslational modifications [PDF]

, 2022
Yanzheng Meng, Lin Zhang, Laizhi Zhang, Ziyu Wang, Xuanwen Wang, Chan Li, Yu Chen, Shipeng Shang, Lei Li   +8 more
openalex   +1 more source

Identifying new drug targets to combat pathogenic infections: an interdisciplinary approach [PDF]

, 2005
Bernaerts, Kristel, Cappuyns, Astrid, De Keersmaecker, Sigrid, De Moor, Bart, Marchal, Kathleen, Mathys, Janick, Monsieurs, Pieter, Smets, Ilse, Sonck, Kathleen, Van Boxel, Nadja, Van den Bulcke, Tim, Van Impe, Jan, Vanderleyden, Jos   +12 more
core   +1 more source

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors [PDF]

, 2014
Kozo Hamada, Akiko Terauchi, Kyoko Nakamura, Takayasu Higo, Nobuyuki Nukina, Nagisa Matsumoto, Chihiro Hisatsune, Takeshi Nakamura, Katsuhiko Mikoshiba   +8 more
openalex   +1 more source

Mass spectrometry‐based mitochondrial proteomics for cancer biomarker discovery

VIEW, EarlyView.
Figure.1 Schematic diagram of MS‐based mitochondrial proteomics for cancer biomarker discovery. The workflow highlights the integration of advanced technological platforms in mitochondrial proteomics and their application in cancer biomarker discovery.
Zheng Cao, ZiKun Song, Weijie Zhou, Xiaohui Liu, Yanling Liu, Peng R. Chen, Kun Qian   +6 more
wiley   +1 more source

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity. [PDF]

Diabetes, 2022
Yang ML, Connolly SE, Gee RJ, Lam TT, Kanyo J, Peng J, Guyer P, Syed F, Tse HM, Clarke SG, Clarke CF, James EA, Speake C, Evans-Molina C, Arvan P, Herold KC, Wen L, Mamula MJ.   +17 more
europepmc   +1 more source