Results 191 to 200 of about 941,378 (248)

Impact of Posttranslational Modification in Pathogenesis of Rheumatoid Arthritis: Focusing on Citrullination, Carbamylation, and Acetylation. [PDF]

Int J Mol Sci, 2021
Kwon EJ, Ju JH.
europepmc   +1 more source

Advanced imaging and multi‐omics to characterize cardiomyocyte ageing and its electrocardiographic imprint in PKP2 arrhythmogenic cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend We used a murine model of cardiomyocyte‐specific conditional knockout of plakophilin 2 (PKP2cKO, middle panel). Using advanced imaging technology, we unveiled distinct hallmarks of premature ageing in PKP2cKO cardiomyocytes, including DNA damage and loss of repressed heterochromatin at the nuclear periphery, and mitochondrial ...
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito, Xianming Lin, Marina Cerrone, Joanna Abi Rizk, Michael Cammer, Yan Deng, Joseph Sall, Mingliang Zhang, Feng‐Xia Liang, Irene de Lázaro, Mario Delmar   +12 more
wiley   +1 more source

Proteome, Lysine Acetylome, and Succinylome Identify Posttranslational Modification of STAT1 as a Novel Drug Target in Silicosis. [PDF]

Mol Cell Proteomics
Zhang T, Wang Y, Sun Y, Song M, Pang J, Wang M, Zhang Z, Yang P, Chen Y, Qi X, Zhou H, Han Z, Xing Y, Liu Y, Li B, Liu J, Yang J, Wang J.   +17 more
europepmc   +1 more source

Age‐ and sex‐specific modulation of human cardiac electrophysiology by doxorubicin

The Journal of Physiology, EarlyView.
Abstract figure legend DOX differentially impacts cardiac electrophysiology based on sex and age. Sex differences were primarily observed among younger hearts, where action potential duration (APD) prolongation was observed in females, but not in males. Created using BioRender. George, S. (2026) https://BioRender.com/wresf1k Abstract Acute doxorubicin (
Sharon A. George, Amber V. Mills, Erin O'Neill, Sofian N. Obaid, Igor R. Efimov, Tatiana Efimova   +5 more
wiley   +1 more source

microRNA‐145‐5p regulates P‐glycoprotein and breast cancer resistance protein in primary human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend Drug transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) at the blood–brain barrier (BBB) protect the rapidly developing fetal brain. We investigated the role of microRNA‐145‐5p (miR‐145‐5p) microRNA (miRNA) in regulating these key transporters in primary human fetal brain endothelial cells in vitro. We
Phetcharawan Lye, Enrrico Bloise, Nikola Ivanovski, Lubna Nadeem, Christopher Casciaro, Stephen G. Matthews   +5 more
wiley   +1 more source

Nonallosteric activation of posttranslational modification enzymes by active site-directed inhibitors. [PDF]

Comput Struct Biotechnol J
Pesaresi A.
europepmc   +1 more source

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Systems‐level phosphoproteomics reveals calcium/calmodulin‐dependent protein kinase kinase 2‐driven kinase signaling underlying malignant phenotypes in gastric cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
CAMKK2 inhibition induces extensive phosphoproteomic remodeling associated with cell cycle regulation, RNA processing, and kinase signaling networks in gastric cancer. Integrated systems‐level analyses identified dysregulated CDK, SRPK, MAPK, and AKT signaling pathways underlying malignant phenotypes and highlighted CAMKK2 as a potential therapeutic ...
Mohd. Altaf Najar, T. S. Keshava Prasad, Prashant Kumar Modi   +2 more
wiley   +1 more source

Integrated Analysis of lncRNA–miRNA–mRNA ceRNA Network in Order to Discover Potential Novel Biomarkers in Stomach Cancer

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Stomach cancer (SC) or gastric cancer (GC) is one of the most common gastrointestinal malignancies. Currently, some studies based on competing endogenous RNAs (ceRNA) network analysis have been assessed for this cancer. The construction and analysis of ceRNA network is a novel approach for identification of RNA‐based biomarkers in cancer ...
Habib MotieGhader, Seyed Mehdi Jazayeri, Reyhaneh Sadat Jazayeri   +2 more
wiley   +1 more source

Unraveling Posttranslational Modification Complexity: Advances in Quantitative Histone Proteoform Mass Spectrometry. [PDF]

Mass Spectrom Rev
Poncha KF, Paparella AT, Young NL.
europepmc   +1 more source