Results 201 to 210 of about 941,378 (248)

Adrenergic Contraction of Human Prostate Tissues Is Maintained Under the Rab GTPase Inhibitors Nexhinib20 and CID1067700

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT α1‐Adrenoceptors are an important drug target in benign prostatic hyperplasia (BPH) and have been intensively studied at the expression level, but their posttranslational regulation in the prostate is widely unknown. Here we examined modulation of prostate smooth muscle contractions by inhibitors for RabGTPases, which are involved in ...
Luca Troffer, Peibin Cen, Michael Brandstetter, Yajie Xu, Patrick Keller, Leo Stadelmeier, Philipp Weinhold, Alexander Tamalunas, Christian G. Stief, Martin Hennenberg   +9 more
wiley   +1 more source

Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation. [PDF]

Proc Natl Acad Sci U S A
Mammeri NE, Dregni AJ, Duan P, Hong M.
europepmc   +1 more source

Profiling Hydrolysis Rates of αS1‐Casein to αS1‐I‐Casein During Cheese Ripening by Intact‐Protein Liquid Chromatography–High Resolution Mass Spectrometry

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale The proteolytic behavior of chymosins during cheese ripening impacts cheese texture, flavor, and quality. Especially, the specific hydrolysis of αS1‐casein to αS1‐I‐casein is relevant for early cheese texture development, and this activity varies between chymosin variants.
Sebastiaan Dolman, Marjolein van der Eijk, Loes Bevers, Kees Muijlwijk, Mee Loke Lim, Margriet Hendriks, Nicolas Abello, Rob van der Hoeven   +7 more
wiley   +1 more source

Automated Multienzyme Digestion Workflows for Confident Characterization of Challenging Posttranslational Modifications in Therapeutic Antibodies by LC–MS/MS

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale Non‐reduced trypsin digestion of therapeutic antibodies can generate large disulfide‐linked peptide complexes that exhibit poor chromatographic and mass spectrometric performance. This limits the confident characterization of posttranslational modifications (PTMs) in specific antibody regions, such as the heavy‐chain constant region ...
Nanna Sofie Eskesen, Yann Leblanc, Justine Lempereur, Martin Ørgaard, Elizabeta Madzharova, Trine M. Sloth, Simon Krabbe, Alexandra K. Rebak, Magali André, Pernille F. Jensen, Dan B. Kristensen   +10 more
wiley   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1368-1378, November 2026.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

Molecular Adaptations and Sex‐Biased Regulatory Pathways in Multi‐Year Diapause of the Cabbage Beetle Colaphellus bowringi: A Duration‐Resolved Transcriptomic Analysis

Ecology and Evolution, Volume 16, Issue 11, November 2026.
This study presents the first multi‐duration, sex‐stratified transcriptomic analysis of prolonged diapause in Colaphellus bowringi, revealing that extended dormancy is maintained by coordinated metabolic suppression and sustained activation of cytoprotective pathways (e.g., glutathione metabolism, autophagy).
Lili Huang, Yan Ni, Xin Ye, Xiaona Liu, Fangsen Xue, Haimin He   +5 more
wiley   +1 more source

Baicalin Alleviates Lactational Heat‐Stress‐Induced Hepatic Mitochondrial Dysfunction via Sirt3‐Dependent Deacetylation of NDUFS1

Food Frontiers, Volume 7, Issue 6, November 2026.
This study reveals that lactational HS suppresses Sirt3 activity, leading to hyperacetylation of the complex I subunit NDUFS1, and excessive mitochondrial ROS production, whereas BAI, a nature food‐derived bioactive compound, alleviates lactational HS‐induced hepatic mitochondrial injury by activating the Sirt3–NDUFS1 axis to deacetylate mitochondrial ...
Jingzheng Li, Honglin Jiang, Jianwen He, Wen Yao   +3 more
wiley   +1 more source

msqrob2PTM: Differential Abundance and Differential Usage Analysis of MS-Based Proteomics Data at the Posttranslational Modification and Peptidoform Level. [PDF]

Mol Cell Proteomics
Demeulemeester N, Gébelin M, Caldi Gomes L, Lingor P, Carapito C, Martens L, Clement L.   +6 more
europepmc   +1 more source

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source