Results 221 to 230 of about 941,378 (248)

Leveraging yeast sequestration to study and engineer posttranslational modification enzymes. [PDF]

Biotechnol Bioeng
Martinusen SG, Denard CA.
europepmc   +1 more source

Defining the conformational landscape of glycogen synthase kinase 3 beta (GSK3β)

Acta Crystallographica Section D, Volume 82, Issue 11, Page 1285-1297, November 2026.
This article presents a systematic structural curation of all deposited GSK3β crystal structures to map its conformational ensemble, revealing eight distinct conformational states.Glycogen synthase kinase 3 beta (GSK3β) is a serine/threonine kinase implicated in Alzheimer's disease, type 2 diabetes, oncology and bipolar disorder, and represents an ...
Akanksha Gurtu, Fernanda Laezza
wiley   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, Volume 179, Issue 3, Page 337-349, November 2026.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source

Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?

Journal of Internal Medicine, Volume 300, Issue 5, Page 572-589, November 2026.
Abstract Hypocholesterolemia is perceived as benign given its association with lower cardiovascular risk. However, genetic and epidemiological evidence indicates that persistently low levels of low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (ApoB) arise from distinct biological mechanisms with different hepatic implications ...
Valentina Flagiello, Emelie Barreby, Umberto Vespasiani‐Gentilucci, Stefano Romeo   +3 more
wiley   +1 more source

Coordination of drought‐adaptive root growth plasticity through auxin homeostasis by the ZmSPL12–ZmYUC5 module in maize

New Phytologist, Volume 252, Issue 4, Page 1526-1544, November 2026.
Proposed model of ZmSPL12‐mediated drought resistance through auxin regulation. Summary Climate change‐induced drought increasingly threatens global maize production. Drought‐adaptive root plasticity in maize depends on auxin signaling, yet how auxin homeostasis is dynamically tuned in response to water deficit remains unclear.
Hua Xu, Lei Ma, Qingyun Zhang, Zhigang Zheng, Jiajing Li, Sen Yang, Yanfeng Zhao, Lian Jin, Binbin Zhao, Zhijing Bai, Jiyuan Cao, Youpeng Tao, Junjie Zou, Baobao Wang, Shujing Cheng, Jinfang Chu, Jiafan Liu, Haiyang Wang, Miaoyun Xu   +18 more
wiley   +1 more source

Rhizobial Symbiosis Enhances Salinity Tolerance in Legumes Through Coordinated Physiological and Molecular Responses: Evidence From Common Vetch and Pea

Plant, Cell &Environment, Volume 49, Issue 11, Page 8912-8931, November 2026.
ABSTRACT Soil salinisation severely constrains crop production. Legumes rely on rhizobial symbiosis for sustainable nitrogen acquisition. Although salinity is known to impair nodulation and nitrogen fixation, how symbiosis influences plant tolerance to salt stress remains unclear.
María Isabel López‐Román, Lucía Zurita, Cristina Castaño‐Herrero, Lucía De la Rosa, Elena Ramírez‐Parra   +4 more
wiley   +1 more source

AKT Phosphorylation of FOXK2 at Ser398 Impacts Breast Cancer Cell Growth and Viability

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Higher FOXK2 protein levels are associated with increased AKT phosphorylation and chemoresistance in breast cancer cells. AKT modulates FOXK2 protein levels, with no such regulation in FOXK2 mRNA levels. GSK3β, a known substrate of AKT (dotted arrow), does not regulate FOXK2 in our cellular model.
L. T. Carneiro, J. M. R. C. Nunes, G. De Gregoriis, B. S. Mendonça, W. M. Araújo, R. C. Maia, E. W. F. Lam, R. S. Carvalho, M. A. Carvalho, A. D. Sharrocks, G. Nestal de Moraes   +10 more
wiley   +1 more source

New FLU mutant alleles point to new insights into singlet oxygen‐mediated signal transduction

New Phytologist, Volume 252, Issue 4, Page 1354-1356, November 2026.
Bernhard Grimm
wiley   +1 more source

The dawn of succinylation: a posttranslational modification

American Journal of Physiology - Cell Physiology, 2018
Posttranslational modifications affect almost all proteins and are critical to a well-functioning and diverse proteome; however, many modifications remain relatively unknown and unstudied.
Narasaiah Kolliputi, Matthew Alleyn, Mason Breitzig   +2 more
exaly   +2 more sources

Considering Protonation as a Posttranslational Modification Regulating Protein Structure and Function [PDF]

Annual Review of Biophysics, 2013
Posttranslational modification is an evolutionarily conserved mechanism for regulating protein activity, binding affinity, and stability.
Matthew P. Jacobson, Diane Barber, Bradley A Webb   +2 more
exaly   +2 more sources