Results 241 to 250 of about 71,707 (290)
ZNF282 Promotes Colorectal Cancer Progression Possibly via E2F1 Activation
Cancer Science, EarlyView.ZNF282 is a zinc finger protein overexpressed in colorectal cancer that facilitates tumor progression by promoting cell cycle progression via E2F1 activation. Our study demonstrates that ZNF282 expression is associated with poor prognosis and may serve as a novel prognostic biomarker and therapeutic target. ABSTRACT Colorectal cancer (CRC) is a leading
Tadashi Abe +23 more
wiley +1 more source
Leveraging yeast sequestration to study and engineer posttranslational modification enzymes. [PDF]
Biotechnol BioengMartinusen SG, Denard CA.
europepmc +1 more source
Pharmaceutically Important Pre- and Posttranslational Modifications on Human Serum Albumin
, 2009 Masaki Otagiri, Victor Tuan Giam Chuang
openalex +2 more sources
Cell Proliferation, EarlyView.Maternal nutrient restriction disrupts placental homeostasis via GAB1 dysregulation—involving both transcriptional downregulation and autophagy‐dependent protein degradation. These molecular alterations inhibit MAPK signalling‐mediated trophoblast fusion, leading to structural and functional deficits in the maternal–fetal exchange interface.
Mingming Fan +9 more
wiley +1 more source
Liquid–Liquid Phase Separation in Major Hallmarks of Cancer
Cell Proliferation, EarlyView.Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie +10 more
wiley +1 more source
The pattern of co-existed posttranslational modifications-A case study
, 2009 Zhengrong Yang
openalex +2 more sources
Osteochondrosis in horses: An overview of genetic and other factors
Equine Veterinary Journal, EarlyView.Abstract Osteochondrosis (OC) is a frequent manifestation of developmental orthopaedic disease, and its severe clinical presentation is known as OC dissecans (OCD). OC is defined as a disruption of the endochondral ossification process in the epiphyseal cartilage, and this disease has been reported in different mammalian species, including humans, dogs,
Lola Martinez‐Saez +2 more
wiley +1 more source
Pathogen-Mediated Posttranslational Modifications: A Re-emerging Field
, 2010 David Ribet, Pascale Cossart
openalex +1 more source
Neocortical neurogenesis: a proneural gene perspective
The FEBS Journal, EarlyView.The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan +3 more
wiley +1 more source
Short coiled‐coil proteins from plants and metazoans – the ‘jacks of all trades’
The FEBS Journal, EarlyView.Short coiled‐coil proteins from plants and metazoans—true ‘jacks of all trades’—play supporting but crucial roles in cellular stress response, metabolism, autophagy, and membrane dynamics. Despite their small size and modest sequence conservation, proteins like plant LSUs and metazoan SCOCs showcase remarkable functional versatility shaped by evolution,
Agnieszka Sirko +2 more
wiley +1 more source