Results 41 to 50 of about 1,756,998 (308)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
THE SOIL AS A NATURAL BODY AND THE ENVIRONMENT FOR PLANTS HABITAT
Бюллетень Почвенного института им. В.В. Докучаева, 2018 The necessity of the doctrine for the soil as a plants habitat environment revival, which appeared in the early stages of the agriculture development, is substanti-ated.
E. S. Migunova
doaj +1 more source
Determination of nitrogen in titanium nitride [PDF]
, 1970 Quantitative determination of nitrogen in titanium nitride involves dissolution of TiN in 10M hydrofluoric acid containing an oxidant. Released nitrogen is determined as ammonia.
Philipp, W. H., Tetzlaff, J. E.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. [PDF]
, 2000 Potassium leak conductances were recently revealed to exist as independent molecular entities. Here, the genomic structure, cardiac localization, and biophysical properties of a murine example are considered.
Buck, ME +4 more
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FEBS Letters, 2003 The atomic structures of K+ channels have added a new dimension to our understanding of K+ channel function. I will briefly review how structures have influenced our views on ion conduction, gating of the pore, and voltage sensing.
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
InorganicsThe kinetic stability provided by the sterically demanding {SiNDipp}2− dianion (SiNDipp = {CH2SiMe2NDipp}2; Dipp = 2,6-i-Pr2C6H3) is intrinsic to the isolation of not only the group 1 alumanyl reagents ([{SiNDipp}AlM]2; M = K, Rb, Cs) but also ...
Han-Ying Liu +3 more
doaj +1 more source
Rice Potassium Transporter OsHAK8 Mediates K+ Uptake and Translocation in Response to Low K+ Stress
Frontiers in Plant Science, 2021 Potassium (K+) levels in the soil often limit plant growth and development. As a result, crop production largely relies on the heavy use of chemical fertilizers, presenting a challenging problem in sustainable agriculture.
Xiaohui Wang +7 more
doaj +1 more source
EFFECTS of FOUR RATES of THREE NITROGEN SOURCES on YIELD and CHEMICAL COMPOSITION of MANCHAR BROMEGRASS FORAGE in the MATANUSKA VALLEY [PDF]
, 1978 Paper copies available in Archives, Acc# 2013-0059List of Tables -- List of Figures -- Summary --Introduction -- Experimental Procedure -- Results and Discussion: Yield, Nitrogen Percentage, Nitrogen Uptake, Nitrogen Recovery, Phosphorus Percentages ...
Laughlin, Winston M.
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