Results 121 to 130 of about 456,361 (296)

Peripheral Analgesic Effect of a Novel Curcuminoid Derivative: Possible Involvement of Peripheral Opioid Receptor and ATP-Sensitive Potassium Ion Channel

Pharmaceutics
Background/Objectives: The present study investigated the local analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone, or BHMC, in a mouse model of peripheral nociception.
Ming Tatt Lee, Yu-Cheng Ho, Chau Ling Tham, Ahmad Akira, Nordin Lajis, Daud Ahmad Israf, Mohd Roslan Sulaiman   +6 more
doaj   +1 more source

Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues

Advanced Healthcare Materials, EarlyView.
Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman, Hadas Oved, Itay Gil, Amgad Marzook, Ester Sapir Baruch, Yahel Shechter, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

Regulation of Kv11.1 Potassium Channel C-Terminal Isoform Expression by the RNA-Binding Proteins HuR and HuD

, 2018
The potassium voltage-gated channel subfamily H member 2 (KCNH2) gene encodes the Kv11.1 potassium channel, which conducts the rapidly activating delayed rectifier current in the heart.
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core  

Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers. [PDF]

, 2001
KCNK subunits have two pore-forming P domains and four predicted transmembrane segments. To assess the number of subunits in each pore, we studied external proton block of Kcnk3, a subunit prominent in rodent heart and brain.
Goldstein, SA, Lopes, CM, Zilberberg, N
core  

Optoelectrical Devices for Neural Interfacing: Engineering Integration, Stability, and Multimodal Sensing

Advanced Healthcare Materials, EarlyView.
Implantable optoelectrical devices are an effective resource for the modulation and monitoring of neural activity with high spatiotemporal resolution. This review discusses current challenges faced by these devices and outlines future perspectives for the development of next‐generation neural interfaces targeting chronic, multisite, and multimodal ...
Stella Aslanoglou, Barbara Spagnolo, Antonio Balena, Massimo De Vittorio, Ferruccio Pisanello   +4 more
wiley   +1 more source

Differential potassium channel inhibitory activities of a novel thermostable degradation peptide BmKcug1a-P1 from scorpion medicinal material and its N-terminal truncated/restored peptides

Scientific Reports
Thermally stable full-length scorpion toxin peptides and partially degraded peptides with complete disulfide bond pairing are valuable natural peptide resources in traditional Chinese scorpion medicinal material. However, their pharmacological activities
Chenhu Qin, Xuhua Yang, Zheng Zuo, Peixin Yuan, Fang Sun, Xudong Luo, Xiangdong Ye, Zhijian Cao, Zongyun Chen, Yingliang Wu   +9 more
doaj   +1 more source

Electrophysiological characteristics of cationic single-channel formed by incorporation of amphotericin b in bilayer lipid membrane [PDF]

, 2016
BACKGROUND AND OBJECTIVE: Amphotericin B (AmB) is the main antibiotic of polyene type, which is widely used in the treatment of systemic fungal infections.
Ashrafpour, M., Sepehri, H., Shahmoradi, T.   +2 more
core  

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, EarlyView.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

Tuning the Testicular Microenvironment for Enhancing Human Sertoli Cells Maturation and Functionality In Vitro

Advanced Healthcare Materials, EarlyView.
An in vitro testicular model is developed by generating connective tissue equivalents from human dermal fibroblast‐derived microtissues and coupling them with human Sertoli cells or human Sertoli cell spheroids. This engineered microenvironment supports Sertoli cell maturation and functionality, providing a promising platform for studying human ...
Annachiara Scalzone, Giorgia Imparato, Chiara Ausilio, Valentina Mollo, Paolo Antonio Netti   +4 more
wiley   +1 more source

Kinetic model based on molecular mechanism for action potential [PDF]

, 2011
The Hodgkin-Huxley model for action potentials has been widely used but was not built on a microscopic description of the neuronal membrane. Through molecular dynamics simulations, the molecular mechanism of the channel currents is becoming clear ...
Lizhong Xu
core   +1 more source