Results 101 to 110 of about 274,660 (308)

Developmental Regulation of Small-Conductance Ca²⁺-Activated K⁺ Channel Expression and Function in Rat Purkinje Neurons

, 2002
Calcium transients play an important role in the early and later phases of differentiation and maturation of single neurons and neuronal networks. Small-conductance calcium-activated potassium channels of the SK type modulate membrane excitability and ...
Stocker, M, Pedarzani P., Stocker, M., Pedarzani, P, Cingolani, L., Cingolani L, Gymnopoulos, M., Boccaccio, A, Cingolani, L. A., Gymnopoulos M, Boccaccio A, Gymnopoulos, Marco, Boccaccio, A., Cingolani, LA, Gymnopoulos, M, Pedarzani, P., Stocker M   +16 more
core   +1 more source

Electrophysiological Mechanism of Catestatin Antiarrhythmia: Enhancement of Ito, IK, and IK1 and Inhibition of ICa‐L in Rat Ventricular Myocytes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiovascular disease remains one of the leading causes of death globally. Myocardial ischemia and infarction, in particular, frequently cause disturbances in cardiac electrical activity that can trigger ventricular arrhythmias.
Ying Zhang, Hua Chen, Qingmin Ma, Hui Jia, Hongyu Ma, Zishuo Du, Yan Liu, Xiangjian Zhang, Yi Zhang, Yue Guan, Huijie Ma   +10 more
doaj   +1 more source

Nicorandil-Induced Hyperkalemia in a Uremic Patient

Case Reports in Medicine, 2012
Nicorandil is an antianginal agent with nitrate-like and ATP-sensitive potassium channel activator properties. After activation of potassium channels, potassium ions are expelled out of the cells, which lead to membrane hyperpolarization, closure of ...
Hung-Hao Lee, Po-Chao Hsu, Tsung-Hsien Lin, Wen-Ter Lai, Sheng-Hsiung Sheu   +4 more
doaj   +1 more source

Neuroprotective effects of potassium channel openers on cerebral ischemia–reperfusion injury in diabetic rats

Bulletin of Faculty of Pharmacy Cairo University, 2017
Objectives: This study was done to estimate the potential neuroprotective role of potassium channel openers in cerebral ischemia–reperfusion (IR) injury in streptozotocin (STZ) induced type-I diabetic rats (T1DR).
Anand B. Pithadia, Shital S. Panchal, Denvanshu J. Patel   +2 more
doaj   +1 more source

POM‐Based Water Splitting Catalyst Under Acid Conditions Driven by Its Assembly on Carbon Nanotubes

Advanced Materials, EarlyView.
A newly‐engineered POM‐based electrocatalyst incorporating non‐innocent counter cations exhibits fast kinetics for either the OER or HER under strongly acidic conditions (1 m H2SO4), depending on whether it is assembled on carbon nanotubes (1@CNT) or physically mixed with them (1/CNT). In water‐splitting tests using a two‐electrode setup, these systems
Eugenia P. Quirós‐Díez, Melanie Guillén‐Soler, Carlos Herreros‐Lucas, Alejandro López‐Moreno, José Manuel Vila‐Fungueiriño, Antonio Luis Llamas‐Saiz, Karol Strutyński, Manuel Melle‐Franco, María del Carmen Giménez‐López   +8 more
wiley   +1 more source

The relationship between apamin binding and channel block in KCa2 potassium channels.

, 2013
Small conductance calcium-activated potassium channels (KCa2.1,2.2,2.3) are widely distributed throughout the body and are involved in diverse physiological processes including the regulation of neuronal firing and smooth muscle contraction.
Jenkinson, DH, Moss, GWJ, Benton, DCH, Garbarg, M   +3 more
core  

K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect

, 2002
Background— Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.
Hubank, M, Stephanou, A., Chanalaris, A., Townsend, P. A., Lawrence, K. M., Townsend, P A, Lawrence, KM, Knight, RA, Ferrari, R., Chanalaris, A, Scarabelli, T., Scarabelli, T, Hubank, M., Pasini, E., Townsend, PA, Latchman, D S, Tinker, A., Latchman, D. S., Knight, R A, Pasini, E, Comini, L, Lawrence, K M, Latchman, DS, Tinker, A, Ferrari, R, Comini, L., Knight, R. A., Stephanou, A   +27 more
core   +1 more source

Flexoelectrically Induced Polar Topology in Twisted SrTiO3 Membranes

Advanced Materials, EarlyView.
Twisted SrTiO3 bilayers host polar vortices of flexoelectric origin, revealed through combined experiment and theory. By reconstructing polarization from the toroidal moment of strain gradients, the work establishes a 3D chiral state with broken inversion and mirror symmetries.
Isabel Tenreiro, Hugo Aramberri, Víctor Rouco, Gabriel Sánchez‐Santolino, Mariona Cabero, Fernando Gallego, David Sánchez‐Manzano, José M. González‐Calbet, Federico Mompeán, Mar García‐Hernández, Alberto Rivera‐Calzada, Jorge Íñiguez‐González, Carlos León, Jacobo Santamaría   +13 more
wiley   +1 more source

N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes

, 2011
Background and Objective: The slow delayed rectifier current (IKs) is important for cardiac action potential termination. The underlying channel is composed of Kv7.1 α-subunits and KCNE1 β-subunits.
Takac, Ina, Ehrlich, Joachim, Zenawit Girmatsion, Biliczki, Peter, Biliczki Peter, Stefan H Hohnloser, Stefan H. Hohnloser, Schwerthelm Christin, Hohnloser, Stefan H., Christin Schwerthelm, Girmatsion, Zenawit, Joachim R. Ehrlich, Hohnloser Stefan H., Ina Takac, Takac Ina, Peter Biliczki, Ehrlich Joachim R., Girmatsion Zenawit, Schwerthelm, Christin, Joachim R Ehrlich   +19 more
core   +1 more source

Electrically Readable Lateral Flow Assay Using Organic Transistors for Diagnostic Applications

Advanced Materials, EarlyView.
Electrolyte‐gated organic field‐effect transistors (EGOFETs) are integrated with lateral flow (LF) paper fluidics to create a reusable, portable, and low‐cost point‐of‐care (PoC) diagnostic test. The devices are validated for Human Immunoglobulin G detection, achieving high sensitivity (0.1 fm), selectivity, and reproducibility with rapid results in 20–
María Jesús Ortiz‐Aguayo, Carme Martínez‐Domingo, Diego Gutiérrez, Dean Kos, Marta Mas‐Torrent   +4 more
wiley   +1 more source