Results 171 to 180 of about 274,660 (308)

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Synthesis of 3- 4-Acyl-2-(1-Methoxy-1-Methylethyl)Morpholin-3-Yl - Benzonitriles as Novel Potassium Channel Openers

, 2009
Potassium channel openers (KCO's) have been demonstrated to possess potent relaxant-activity on smooth muscle. Tissue- selective KCO's may find use in the treatment of a variety of diseases, such as hypertension, asthma, and urinary incontinence. We have
林美香;忻凌偉;程正禹, LIN, MEI-SHAN;HSIN, LING-WEI;CHENG, CHEN-YU   +1 more
core  

Genetic Variants in Potassium Channel Genes and Their Clinical Implications in Kazakhstani Patients with Cardiac Arrhythmias. [PDF]

J Pers Med
Chamoieva A, Rakhimova S, Abilova Z, Akhmetova A, Akilzhanova G, Zhalbinova M, Daniyarov A, Akilzhanov K, Molkenov A, Kairov U, Kuanysheva A, Shaimardanov N, Abdrakhmanov A, Bekbossynova M, Akilzhanova A.   +14 more
europepmc   +1 more source

Physical Origin of Temperature Induced Activation Energy Switching in Electrically Conductive Cement

Advanced Science, EarlyView.
The temperature‐induced Arrhenius activation energy switching phenomenon of electrical conduction in electrically conductive cement originates from structural degradation within the biphasic ionic‐electronic conduction architecture and shows percolation‐governed characteristics: pore network opening dominates the low‐percolation regime with downward ...
Jiacheng Zhang, Xinyuan Ke, Andrew Heath, Richard J. Ball, Jiawei Xie, Jinchen Fan, Guisheng Li, Kevin Paine   +7 more
wiley   +1 more source

Bioactive lipid-mediated structural and functional regulation of the essential human potassium channel Kir7.1. [PDF]

Nat Commun
Niu Q, Vu S, Xu Y, Qian M, Rudenko A, Ye J, Zeng J, Huang W, Covey DF, Zhang R, Fu Z, Lishko PV.   +11 more
europepmc   +1 more source

Displacive In‐Plane Ferroelectricity with Domain‐Specific Curie Temperature in Van der Waals Semiconductors

Advanced Science, EarlyView.
Temperature‐dependent electron diffraction on tin monochalcogenides demonstrates a gradual displacive transformation between ferroelectric and paraelectric phases with significant variability in lattice constants and Curie temperature (TC). Periodic variations exist even between domains in individual crystals, implying a domain‐specific Curie ...
Peter Sutter, Eli Sutter
wiley   +1 more source

The role of humoral autoimmunity in gastrointestinal neuromuscular diseases

, 2010
PhDDysfunction of the gastrointestinal neuromuscular apparatus (including interstitial cells of Cajal) is presumed to underlie a heterogeneous group of disorders collectively termed gastrointestinal neuromuscular diseases (GINMDs).
Hubball, Andrew William
core  

Molecular Basis of the Inhibition of Voltage-Gated Potassium Channel Kv1.1 by Chinese Tarantula Peptide Huwentoxin-XI. [PDF]

Toxins (Basel)
Luo X, Yin Y, Wang F, Li X, Wang S, Yang Y, Zheng C, Liu J, Deng M.   +8 more
europepmc   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

The TWK-26/KCNK3 potassium channel and FLR-4 protein kinase coordinate nutrient absorption in the C. elegans intestine. [PDF]

Genetics
Torzone SK, Carroll T, Breen PC, Cohen NR, Simmons KN, VanDerMolen KR, Schmidt AM, Nehrke KW, Dowen RH.   +8 more
europepmc   +1 more source