Results 221 to 230 of about 456,361 (296)

Activation of Kv11.1 potassium channel suppresses non-small cell lung cancer growth by promoting c-Myc degradation. [PDF]

Commun Biol
Eskandari N, Delisi D, O'Neil R, Bocchetta M, Gentile S.   +4 more
europepmc   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Structure of the human TWIK-2 potassium channel and its inhibition by pimozide. [PDF]

Proc Natl Acad Sci U S A
Khanra NK, Wang C, Delgado BD, Long SB.
europepmc   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

Protocol to study human Kv1.2 potassium channel pathogenic sequence variants using two-electrode voltage-clamp technique. [PDF]

STAR Protoc
Manville RW, Abbott GW.
europepmc   +1 more source

Nanoarchitectonics of Porous Carbons Templated by Inorganic Metal Oxides and Alkali Metal Salts for Energy and Environmental Applications

Advanced Science, EarlyView.
This review explores inorganic metal oxides and metal salt nanoparticles templated porous carbons, highlighting their synthesis, structural features, and performance in energy and environmental applications. It critically compares template types, porosity control, and functional outcomes across recent literature.
Gurwinder Singh, Jibi Kunjumon, Harleen Kaur, Narinder Singh, Gregory Franklin, Arpita Pandey Tiwari, Lukas Van Zweiten, John Kennedy, Ajayan Vinu   +8 more
wiley   +1 more source

Design and In Vitro Evaluation of Cross-Linked Poly(HEMA)-Pectin Nano-Composites for Targeted Delivery of Potassium Channel Blockers in Cancer Therapy. [PDF]

Gels
Civir GO, Bahadori F, Ozay O, Ergin Kızılçay G, Atesoglu S, Aldogan EH, Celik B.   +6 more
europepmc   +1 more source

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source

Minoxidil and nebivolol restore aortic elastic fiber homeostasis in diabetic mice via potassium channel activation. [PDF]

Front Physiol
Henry A, Vanalderwiert L, Oszust F, Wahart A, Carvajal Berrio DA, Brauchle EM, Schenke-Layland K, Brinckmann J, Steenbock H, Debelle L, Six I, Faury G, Jaisson S, Gillery P, Durlarch V, Sartelet H, Maurice P, Bennasroune A, Martiny L, Duca L, Romier B, Blaise S.   +21 more
europepmc   +1 more source

Displacive In‐Plane Ferroelectricity with Domain‐Specific Curie Temperature in Van der Waals Semiconductors

Advanced Science, EarlyView.
Temperature‐dependent electron diffraction on tin monochalcogenides demonstrates a gradual displacive transformation between ferroelectric and paraelectric phases with significant variability in lattice constants and Curie temperature (TC). Periodic variations exist even between domains in individual crystals, implying a domain‐specific Curie ...
Peter Sutter, Eli Sutter
wiley   +1 more source