Results 221 to 230 of about 1,714,984 (295)

A scaffold attachment factor PHM-2 regulates synaptic transmission through SLO-2 potassium channel in C. elegans. [PDF]

PLoS Genet
Niu L, Murugasen K, Hanggodo S, Ferdousy S, Zhu L, Chen B.   +5 more
europepmc   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

Optogenetic silencing by combining a rhodopsin cyclase with an engineered cGMP-gated potassium channel. [PDF]

Sci Adv
Spreen A, Sadanandan NP, Schneider MW, Kuehn E, Leemisa AN, De Zio R, Meyer N, Busse W, Erlinghagen B, Adenauer L, Opitz T, Bönigk W, Schiewer E, Heer J, Schmitz D, Vierock J, Beck H, Hegemann P, Baier H, Schneider-Warme F, Sierra YAB, Seifert R.   +21 more
europepmc   +1 more source

Oxygen‐Assisted MOCVD Growth of Monolayer PtSe2 Films With Bandgap Opening for Semiconducting FET Channels

Advanced Science, EarlyView.
Monolayer PtSe2 films are successfully grown via optimized MOCVD, achieving uniform coverage over a 1.5 cm × 1.5 cm area. Oxygen‐assisted growth effectively removes carbon impurities, ensuring high film quality. Array‐level FETs based on monolayer PtSe2 channels demonstrate low off‐current and high ION/IOFF ratios, highlighting the potential of PtSe2 ...
Yuseok Kim, Hee‐Soo So, Minseok Yoo, Saeyoung Oh, Dongyoung Kim, Minseung Gyeon, Min‐Kyung Jo, Gichang Noh, Tae Soo Kim, Min‐gyu Kim, Jeongwon Park, Hyun‐Jun Chai, Minsoo Kang, Suhyun Kim, Ayoung Ham, Jaehyun Lee, Jongsun Lim, Seungwoo Song, Joon Young Kwak, Seunghwan Seo, Chang‐Soo Lee, Chang Gyoun Kim, Kibum Kang   +22 more
wiley   +1 more source

A physiologically-relevant intermediate state structure of a voltage-gated potassium channel. [PDF]

Nat Commun
Kyriakis E, Sastre D, Eldstrom J, Roscioni A, Russo S, Ataei F, Dou Y, Chan M, Molinarolo S, Maragliano L, Van Petegem F, Fedida D.   +11 more
europepmc   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Large-scale functional assessment of variants of the potassium channel Kir2.1: Clinical and comparative insights. [PDF]

J Biol Chem
Anderson CL, Munuwar S, Walters JK, McWilliams SF, Melnick M, Langer ER, Bereslavskyy I, Milaitis MR, Reilly L, Eckhardt LL.   +9 more
europepmc   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

Shaker potassium channel mediates an age-sensitive neurocardiac axis regulating sleep and cardiac function in Drosophila. [PDF]

Biogerontology
Madamanchi K, Bannister D, Docuyanan A, Bhide S, Melkani GC.   +4 more
europepmc   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source