Results 201 to 210 of about 12,064 (247)

Inwardly rectifying potassium channels in rat retinal ganglion cells

European Journal of Neuroscience, 2004
AbstractInwardly rectifying potassium channels (Kir channels) are important for neuronal signalling and membrane excitability. In the present work we characterized, for the first time, Kir channels in rat retinal ganglion cells (RGCs), the output neurons in the retina, using immunocytochemical and patch‐clamp techniques.
Jing-Wei Zhao, Xiong-Li Yang
exaly   +3 more sources

Channelopathies of inwardly rectifying potassium channels

The FASEB Journal, 1999
ABSTRACT Mutations in genes encoding ion channels have increasingly been identified to cause disease conditions collectively termed channelopathies. Recognizing the molecular basis of an ion channel disease has provided new opportunities for screening, early diagnosis, and therapy of such conditions. This synopsis
M R, Abraham, A, Jahangir, A E, Alekseev, A, Terzic   +3 more
openaire   +2 more sources

Inwardly Rectifying Potassium Channels in the Regulation of Vascular Tone

Current Drug Targets, 2003
Potassium ion (K+) channel activity is one of the major determinants of vascular muscle cell membrane potential and thus vascular tone. Four types of K+ channels are functionally important in the vasculature-Ca(2+)-activated K+ (KCa) channels, voltage-dependent K+ (Kv) channels, ATP-sensitive K+ (KATP) channels, and inwardly rectifying K+ (KIR ...
Sophocles, Chrissobolis, Christopher G, Sobey   +1 more
openaire   +2 more sources

Expression of an Inwardly Rectifying Potassium Channel in Xenopus Oocytes

Journal of Neurochemistry, 1992
Abstract: The murine macrophage‐like cell line J774.1 was used as a source of mRNA for the expression of inwardly rectifying potassium channels in Xenopus oocytes. RNA was isolated, poly(A)+‐selected, and size‐fractionated by sucrose density gradient centrifugation.
F, Périer, K L, Coulter, C M, Radeke, C A, Vandenberg   +3 more
openaire   +2 more sources

ATP-sensitive and inwardly rectifying potassium channels in smooth muscle

Physiological Reviews, 1997
The properties and roles of ATP-sensitive (KATP) and inwardly rectifying (KIR) potassium channels are reviewed. Potassium channels regulate the membrane potential of smooth muscle, which controls calcium entry through voltage-dependent calcium channels, and thereby contractility through changes in intracellular calcium.
Quayle, J. M., Nelson, M. T.; id_orcid 0000-0002-6608-8784, Standen, N. B.   +2 more
openaire   +3 more sources

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

Physiological Reviews, 2010
Inwardly rectifying K+(Kir) channels allow K+to move more easily into rather than out of the cell. They have diverse physiological functions depending on their type and their location. There are seven Kir channel subfamilies that can be classified into four functional groups: classical Kir channels (Kir2.x) are constitutively active, G protein-gated ...
Hiroshi, Hibino, Atsushi, Inanobe, Kazuharu, Furutani, Shingo, Murakami, Ian, Findlay, Yoshihisa, Kurachi   +5 more
openaire   +2 more sources

β‐Adrenergic Modulation of Glial Inwardly Rectifying Potassium Channels

Journal of Neurochemistry, 1995
Abstract: Cultured spinal cord astrocytes (2–13 days in vitro) express several different potassium current types, including delayed rectifier, transient A‐type, and inward rectifier (Kir) K+ currents. Of these, Kir is believed to be of critical importance in the modulation of extracellular [K+] in the CNS. Using the whole‐cell patch‐clamp technique, we
M L, Roy, H, Sontheimer
openaire   +2 more sources

Channelopathies of Cardiac Inwardly Rectifying Potassium Channels

2008
Diseases resulting from impaired ion channel function—channelopathies—are increasingly recognized pathologies in human cardiovascular medicine.1 Understanding the molecular basis of an ion channel disease has provided new opportunities for screening, early diagnosis, and therapy of these commonly life-threatening conditions. 2, 3 A case in point is the
Andre Terzic, Michel Vivaudou, Christophe Moreau, Timothy M. Olson, Arshad Jahangir, Leonid V. Zingman, Alexey E. Alekseev   +6 more
openaire   +1 more source

Cloning and expression of an inwardly rectifying ATP-regulated potassium channel

Nature, 1993
A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanning helices and a proposed ATP-binding domain, represents a major departure from the basic structural design characteristic of voltage-gated and second messenger ...
K, Ho, C G, Nichols, W J, Lederer, J, Lytton, P M, Vassilev, M V, Kanazirska, S C, Hebert   +6 more
openaire   +2 more sources

Direct Activation of an Inwardly Rectifying Potassium Channel by Arachidonic Acid

Molecular Pharmacology, 2001
Arachidonic acid (AA) is an important constituent of membrane phospholipids and can be liberated by activation of cellular phospholipases. AA modulates a variety of ion channels via diverse mechanisms, including both direct effects by AA itself and indirect actions through AA metabolites.
Y, Liu, D, Liu, L, Heath, D M, Meyers, D S, Krafte, P K, Wagoner, C P, Silvia, W, Yu, M E, Curran   +8 more
openaire   +2 more sources