Results 201 to 210 of about 19,097 (250)

Nonsteroidal Anti-Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies. [PDF]

ChemMedChem
Laghetti P, Altamura C, Dell'Atti S, Desaphy JF, Saltarella I.   +4 more
europepmc   +1 more source

GABA_B Receptor Modulation of Membrane Excitability in Human Pluripotent Stem Cell-Derived Sensory Neurons by Baclofen and α-Conotoxin Vc1.1. [PDF]

J Neurochem
St Clair-Glover M, Yousuf A, Kaul D, Dottori M, Adams DJ.   +4 more
europepmc   +1 more source

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Review on Regulation of Inwardly Rectifying Potassium Channels

Critical Reviews in Eukaryotic Gene Expression, 2011
An inwardly rectifying potassium channel (Kir) is a kind of protein complex that is widely expressed on excitable and nonexcitable cell membranes. Kir channels serve important roles in cellular physiology such as cell excitability and K+ homeostasis. The Kirs (KIR1-7) are regulated by many factors: phosphatidylinosital-4, 5-bisphosphate (PIP2), ATP, or
Junshuai, Wang, Yuancheng, Huang, Qin, Ning   +2 more
exaly   +3 more sources

Inwardly rectifying potassium channels in rat retinal ganglion cells

European Journal of Neuroscience, 2004
AbstractInwardly rectifying potassium channels (Kir channels) are important for neuronal signalling and membrane excitability. In the present work we characterized, for the first time, Kir channels in rat retinal ganglion cells (RGCs), the output neurons in the retina, using immunocytochemical and patch‐clamp techniques.
Jing-Wei Zhao
exaly   +3 more sources

Channelopathies of inwardly rectifying potassium channels

The FASEB Journal, 1999
ABSTRACT Mutations in genes encoding ion channels have increasingly been identified to cause disease conditions collectively termed channelopathies. Recognizing the molecular basis of an ion channel disease has provided new opportunities for screening, early diagnosis, and therapy of such conditions. This synopsis
M R, Abraham, A, Jahangir, A E, Alekseev, A, Terzic   +3 more
openaire   +2 more sources

β‐Adrenergic Modulation of Glial Inwardly Rectifying Potassium Channels

Journal of Neurochemistry, 1995
Abstract: Cultured spinal cord astrocytes (2–13 days in vitro) express several different potassium current types, including delayed rectifier, transient A‐type, and inward rectifier (Kir) K+ currents. Of these, Kir is believed to be of critical importance in the modulation of extracellular [K+] in the CNS. Using the whole‐cell patch‐clamp technique, we
M L, Roy, H, Sontheimer
openaire   +2 more sources

Channelopathies of Cardiac Inwardly Rectifying Potassium Channels

2008
Diseases resulting from impaired ion channel function—channelopathies—are increasingly recognized pathologies in human cardiovascular medicine.1 Understanding the molecular basis of an ion channel disease has provided new opportunities for screening, early diagnosis, and therapy of these commonly life-threatening conditions. 2, 3 A case in point is the
Andre Terzic, Michel Vivaudou, Christophe Moreau, Timothy M. Olson, Arshad Jahangir, Leonid V. Zingman, Alexey E. Alekseev   +6 more
openaire   +1 more source

ATP-sensitive and inwardly rectifying potassium channels in smooth muscle

Physiological Reviews, 1997
The properties and roles of ATP-sensitive (KATP) and inwardly rectifying (KIR) potassium channels are reviewed. Potassium channels regulate the membrane potential of smooth muscle, which controls calcium entry through voltage-dependent calcium channels, and thereby contractility through changes in intracellular calcium.
Quayle, J. M., Nelson, M. T., Standen, N. B.   +2 more
openaire   +3 more sources

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

Physiological Reviews, 2010
Inwardly rectifying K+(Kir) channels allow K+to move more easily into rather than out of the cell. They have diverse physiological functions depending on their type and their location. There are seven Kir channel subfamilies that can be classified into four functional groups: classical Kir channels (Kir2.x) are constitutively active, G protein-gated ...
Hiroshi, Hibino, Atsushi, Inanobe, Kazuharu, Furutani, Shingo, Murakami, Ian, Findlay, Yoshihisa, Kurachi   +5 more
openaire   +2 more sources

Inwardly Rectifying Potassium Channels in the Regulation of Vascular Tone

Current Drug Targets, 2003
Potassium ion (K+) channel activity is one of the major determinants of vascular muscle cell membrane potential and thus vascular tone. Four types of K+ channels are functionally important in the vasculature-Ca(2+)-activated K+ (KCa) channels, voltage-dependent K+ (Kv) channels, ATP-sensitive K+ (KATP) channels, and inwardly rectifying K+ (KIR ...
Sophocles, Chrissobolis, Christopher G, Sobey   +1 more
openaire   +2 more sources