In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García+23 more
wiley +1 more source
The role of potassium channels and calcium in the relaxation mechanism of magnesium sulfate on the isolated rat uterus [PDF]
MgSO4 is used as a tocolytic agent. It is considered to be a calcium channel antagonist, but a different mechanism of its action might be involved. The aim of this study was to examine the contribution of calcium concentrations and potassium channels in ...
Sokolović Dragana+6 more
doaj +1 more source
Effect Of Site Selective Ion Channel Blocking on Action Potential [PDF]
In this work we have theoretically investigated how the action potential generation and its associated intrinsic properties are affected in presence of ion channel blockers by adapting Gillepie's stochastic simulation technique on a very basic neuron of Hodgkin-Huxley type.
arxiv
Correlation studies of open and closed states fluctuations in an ion channel: Analysis of ion current through a large conductance locust potassium channel [PDF]
Ion current fluctuations occurring within open and closed states of large conductance locust potassium channel (BK channel) were investigated for the existence of correlation. Both time series, extracted from the ion current signal, were studied by the autocorrelation function (AFA) and the detrended fluctuation analysis (DFA) methods.
arxiv +1 more source
Sonochemical Functionalization of Glass
A new method for functionalizing glass using ultrasonication of aryl diazonium salts. Aryl radicals generated by ultrasounds react with glass, forming a stable, covalently bonded organic film. The functionalized glass adheres microorganisms such as microalgae, fungi, and bacteria, suggesting potential applications in enzyme production, filtration ...
Tiexin Li+13 more
wiley +1 more source
What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Benyhe, Sándor+11 more
core
Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels. [PDF]
A 2 P domain potassium channel expressed in eye, lung, and stomach, Kcnk8, has recently been identified. To initiate further biochemical and genetic studies of this channel, we assembled the murine Kcnk8 cDNA sequence, characterized the genomic structure
Bockenhauer, D+4 more
core +1 more source
The potassium channels were recently found to be inhibited by animal toxin-like human β-defensin 2 (hBD2), the first defensin blocker of potassium channels. Whether there are other defensin blockers from different organisms remains an open question. Here,
Fang Xiang+7 more
doaj +1 more source
Enhancement of Kv1.3 Potassium Conductance by Extremely Low Frequency Electromagnetic Field [PDF]
Theoretical and experimental evidences support the hypothesis that extremely low-frequency electromagnetic fields can affect voltage-gated channels. Little is known, however, about their effect on potassium channels. Kv1.3, a member of the voltage-gated potassium channels family originally discovered in the brain, is a key player in important ...
arxiv
Renal potassium channels: An overview [PDF]
The introduction of the patch-clamp technique by Neher and Sackmann [1, 2] has led to the successful exploration of potassium (K) channels in the kidney, allowing the definition of their properties, localization along the nephron and their regulation [3–6].
openaire +2 more sources