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Pharmacology of Cardiac Potassium Channels [PDF]
Cardiac K(+) channels are cardiomyocyte membrane proteins that regulate K(+) ion flow across the cell membrane on the electrochemical gradient and determine the resting membrane potential and the cardiac action potential morphology and duration. Several K(+) channels have been well studied in the human heart.
Li, GR, Dong, MQ
openaire +5 more sources
A novel polymer electrolyte membrane with a hyperbranched interpenetrating hydrogen bond network structure is developed. The unique structure of the hyperbranched polymer contributes to a high glass transition temperature exceeding 400 °C, enabling its operation at elevated temperatures for fuel cell applications.
Lingping Zeng+10 more
wiley +1 more source
High temperature sensitivity is intrinsic to voltage-gated potassium channels. [PDF]
Temperature-sensitive transient receptor potential (TRP) ion channels are members of the large tetrameric cation channels superfamily but are considered to be uniquely sensitive to heat, which has been presumed to be due to the existence of an ...
Yang, Fan, Zheng, Jie
core +3 more sources
A Strong and Water‐Retaining Biomass Adhesive Inspired by Tofu
Drawing inspiration from the formation mechanism of the traditional food tofu, a strong and water‐retaining adhesive is designed using the soybean meal (SM) oxidized by glucose oxidase (GOx) and calcium sulfate oligomer (CSO). This design strategy effectively addresses the conflicting requirements of water‐resistant bonding strength and water retention
Jiawei Shao+8 more
wiley +1 more source
The conduction pathway of potassium channels is water free under physiological conditions. [PDF]
Ion conduction through potassium channels is a fundamental process of life. On the basis of crystallographic data, it was originally proposed that potassium ions and water molecules are transported through the selectivity filter in an alternating ...
Chevelkov, V.+9 more
core +1 more source
Tuning the Hydrogen Bond Network Inside the Helmholtz Plane for Industrial Hydrogen Evolution
The hydrogen bond network within the Helmholtz plane, a key component affecting the hydrogen evolution kinetics, remains far from having a consensus owing to the lack of fundamental understanding. Herein, it is discovered that the introduction of the atomic electric field generated by the weak Ru─Ga bonds can further improve the proportion of 4 ...
Xinyu Chen+9 more
wiley +1 more source
A series of ACHPES‐based hydrogels are developed and realizing multiple functions like anti‐fouling properties, alkali‐induced color/fluorescence‐changing ability and strain sensing. Furthermore, the hydrogels show excellent anti‐freezing performance, whose optical, mechanical and electrical properties remain stable at −47.3 °C.
Gaopeng Wang+9 more
wiley +1 more source
This study investigates nanoscale temperatures generated by photoexcited gold nanostars and their correlation with microscale thermal damage at the cellular level. Using X‐ray absorption spectroscopy and confocal microscopy in 3D cancer spheroids, it assesses localized heating effects and examines tumor cell structure and integrity, offering insights ...
Rosalía López‐Méndez+11 more
wiley +1 more source
Biomimetic potassium selective nanopores [PDF]
Reproducing the exquisite ion selectivity displayed by biological ion channels in artificial nanopore systems has proven to be one of the most challenging tasks undertaken by the nanopore community, yet a successful achievement of this goal offers immense technological potential.
arxiv
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto+2 more
wiley +1 more source