Results 81 to 90 of about 238,668 (318)
Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, EarlyView.This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source
Boosting potato supply and demand in Southeast Asia. Project profile
, 2019 Potato has unexploited potential to contribute to the food security, nutrition, and livelihoods of resource-poor farmers in Southeast Asia. This project aims to identify suitable varieties that are early-maturing, high-yielding, disease-resistant and ...
International Potato Center
core
Advanced Science, EarlyView.FAK signaling drives chemoresistance and tumor evolution in pancreatic ductal adenocarcinoma. The FAK inhibitor IN10018 restores gemcitabine sensitivity by inducing SLC7A11‐mediated ferroptosis through the PI3K‐Akt pathway and remodeling the tumor microenvironment, reducing mesenchymal components while enhancing CD8+ T‐cell infiltration in preclinical ...
Yingjin Wang +11 more
wiley +1 more source
New sources of resistance to potato late blight disease in Peru. Project profile.
, 2020 Late blight disease in potato is possibly the most devastating crop disease in history. This project seeks to identify new sources of resistance in landraces and wild relatives, which could be used in potato breeding programs around the world to mitigate
International Potato Center
core
Towards F1 Hybrid Seed Potato Breeding
, 2011 Compared to other major food crops, progress in potato yield as the result of breeding efforts is very slow. Genetic gains cannot be fixed in potato due to obligatory out-breeding.
Meijer, D.A. +6 more
core +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
, 2016 This final report presents the performance of the project “Potato Production Support and Research to Improve Food Security in Khatlon, Tajikistan”, implemented by the International Potato Center (CIP) and funded by the U.S.
International Potato Center
core
Hydrothermal Humification of Biomass for Circular Carbon Management in Sustainable Agro‐Ecosystems
Advanced Science, EarlyView.This article provides a comprehensive overview of biomass hydrothermal humification for building sustainable agro‐ecosystems. It examines the chemical transformation mechanisms and the functional benefits of the produced humic acids in soil remediation.
Ziyun Liu +4 more
wiley +1 more source
Promoting nutrition-sensitive potato value chains in Kenya. Project profile.
, 2019 Potato has underexploited potential to contribute to food security and incomes among Kenyan smallholders. This project builds on the past work of the International Potato Center (CIP) to increase the current low levels of productivity.
International Potato Center
core
Ecuador Potato Middlemen Survey
, 2016 Ecuador potato middlemen survey is the study of the middlemen in the potatoes value chain in Ecuador. These data allow quantifying the extent of food loss at the middlemen level using consistent approaches that are comparable across commodities and ...
International Potato Center (CIP) +1 more
core +1 more source