Results 231 to 240 of about 583,846 (360)

When the team potency needs self-efficacy and adaptive selling

, 2019
Karin Borges Senra, Letícia Fernandes de Negreiros, Valter Afonso Vieira   +2 more
openalex   +2 more sources

Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies

, 2020
Brian H. Santich, Jeong A Park, Hoa Tran, Hong-Fen Guo, Morgan Huse, Nai‐Kong V. Cheung   +5 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Comparison of the potency-ratio of ciprofol and propofol on sedative effects in painless hysteroscopy: a randomized double-blind dose-response study. [PDF]

BMC Anesthesiol
Zhang Y, Chen X, Jin L, Chen X, Qian X.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Fluorinated pyrimidine 5-carboxamides as potential tools for MERTK targeted fluorine-18-PET-radioligand development. [PDF]

RSC Med Chem
Mudududdla R, Wong SW, Nguyen N, Xue L, Stashko MA, Wang X, Vivash L, Binder MD, Ackermann U, Bozikis YE, Kilpatrick TJ, Baell JB.   +11 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Enhancement of the Antioxidant Activity of <i>Hedysari Radix</i> Particle Dispersion via ZIF-8/PEG Surface Co-Adsorption. [PDF]

Molecules
Han X, Wang C, Wang J, Pan Q, Feng J, Zuo G.   +5 more
europepmc   +1 more source

Enhanced potency of the metalloprotease inhibitor TAPI-2 by multivalent display

, 2014
Aram Raissi, Frank A. Scangarello, Kaitlin R. Hulce, Jason K. Pontrello, Suzanne Paradis   +4 more
openalex   +1 more source

A POTENCY TEST OF TUBERCULIN

Japanese Journal of Medical Science and Biology, 1953
openaire   +7 more sources