Results 231 to 240 of about 500,827 (300)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A product control framework for extracellular vesicle therapeutics: Quality attributes, stability, analytical procedures, and biodistribution. [PDF]

Int J Pharm X
Moon H, Jung SH, Bae S, Bae G, Lee A, Na JH, Kim JH, Choi JU, Lee S.   +8 more
europepmc   +1 more source

A small molecule inhibits Ebola virus entry through glycoprotein stabilization. [PDF]

Nat Commun
Bu F, Ye G, Sharma KL, La Rosa B, Palaniappan M, Matzuk MM, Young DW, Turner-Hubbard H, Morsheimer K, Owen C, Toth K, Cameron M, Davey R, Chamakuri S, Dosa P, Li F.   +15 more
europepmc   +1 more source

Targeting PIKfyve: Chemical Biology and Drug Discovery Insights. [PDF]

Chem Biol Drug Des
Selvam AAA, Sharma A.
europepmc   +1 more source