Results 91 to 100 of about 83,622 (308)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Examining the Impact of Green Intellectual Capital on Green Business Strategies: The Key Role of Absorptive Capacity and Environmental Ethics [PDF]

مطالعات مدیریت توسعه سبز
Introduction:In today's knowledge-based economy, focusing on intellectual capital is vital for maintaining competitiveness. Intellectual capital serves as a foundation for new resources that organizations can leverage to compete effectively.
Mohsen Forghani, Sasan Salehi
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

University absorptive capacity: Normative and perceived assessments

Управленец
Knowledge management in universities is a dual process combining continuous learning and development of academic staff with the simultaneous transfer of knowledge to students.
Svetlana V. Orekhova, O.M. Nikitina, Natalya Yu. Yaroshevich   +2 more
doaj   +1 more source

China's absorptive State: research, innovation and the prospects for China-UK collaboration [PDF]

, 2013
China's innovation system is advancing so rapidly in multiple directions that the UK needs to develop a more ambitious and tailored strategy, able to maximise opportunities and minimise risks across the diversity of its innovation links to China. For the
Adams, Jonathan, Bound, KIrsten, Saunders, Tom, Wilsdon, James   +3 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Absorptive Capacity of Schools [PDF]

This article presents the concept of absorptive capacity as the potential to identify, assimilate, recognize the value of external knowledge. The aim of this article is to present the results of expert interviews with principals of primary and ...
Lenart, Regina
core  

A knowledge creation perspective on ‘LEAN’ approaches to policing in England and Wales [PDF]

, 2015
The police service in England and Wales continue to face intense pressures to manage and reduce budgets while simultaneously maintaining and improving levels of service.
Barton, H, Matthews, RL
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Open Innovation in SMEs: Potential and Realized Absorptive Capacity for Interorganizational Learning in Dyad Collaborations with Academia

Journal of Open Innovation: Technology, Market and Complexity, 2019
Due to a variety of barriers to develop innovation, small and medium enterprises (SMEs) find it necessary to collaborate with external sources of knowledge.
Grover Alfredo Avalos-Quispe, Luis Manuel Hernández-Simón   +1 more
doaj   +1 more source