Results 71 to 80 of about 17,775 (300)

The Effect of Knowledge-based Culture on Strategic Innovation with Regard to Knowledge Absorptive Capacity and Strategic Flexibility [PDF]

مطالعات مدیریت راهبردی, 2017
The main objective of this study was to examine the effect of knowledge culture on strategic innovation in companies located in Tehran University's Science and Technology Park.
Shahram Khalilnezhad, Mohammad Reza Daneshvar   +1 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Under-Developed Social Integration Mechanism as Moderating Factor of Two-Dimensional Absorptive Capacity Relationship: Systematic Literature Review

SAGE Open
The study aims to answer how and what kind of the social integration mechanisms may influence the relationship between the two dimensions of absorptive capacity which is, potential absorptive capacity (PACAP) and realized absorptive capacity (RACAP). The
Asri Pertiwi, Tirta Nugraha Mursitama, Jap Tji Beng, Elidjen   +3 more
doaj   +1 more source

Does absorptive capacity foster open innovation? Examining the impact of innovativeness and risk-taking on the innovative performance of tourism firms

Journal of Open Innovation: Technology, Market and Complexity
To maintain competitiveness and sustainability, firms must implement a combination of internal and external strategies that enhance their innovation potential. This study identifies absorptive capacity (ACAP) as a strategic antecedent of open innovation (
Bernardo De la Gala-Velásquez, Américo Hurtado-Palomino, Patricia Pilar Zirena-Bejarano, Angela Yuliana Arredondo-Salas   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Combined Influence of Absorptive Capacity and Corporate Entrepreneurship on Performance [PDF]

, 2019
Drawing on a dynamic capabilities perspective and a resource-based view, this article analyzes the relationship between absorptive capacity and corporate entrepreneurship, and their combined e ect on organizations’ performance.
García Morales, Víctor Jesús, Víctor J. García-Morales, Luis M. Molina, Jiménez Barrionuevo, María Magdalena, M.ª Magdalena Jiménez-Barrionuevo, Molina Fernández, Luis Miguel   +5 more
core   +1 more source

R&D Spillovers with Endogenous Absorptive Capacity: Lessons for Developing Countries

East Asian Economic Review, 2016
This paper analyzes the role of absorptive capacity in R&D spillovers through strategic R&D investments in a game-theoretic framework. In the model, a firm's effective R&D is composed of idiosyncratic R&D, which produces its own innovations, and ...
Chankwon Bae
doaj   +1 more source

The impact of dynamic marketing capabilities on startup performance: A case of business incubators in Jordan [PDF]

Innovative Marketing
Dynamic marketing capabilities provide startups with the platform and market knowledge that entitle them to achieve their goals and survive the competition.
Hamza Salim Khraim
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source