Results 81 to 90 of about 17,775 (300)

Relações entre capacidade de absorção de conhecimento, sistemas de memória organizacional e desempenho financeiro [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia e Gestão do Conhecimento, Florianópolis, 2013.Abstract : This study focuses on the important issue of measuring absorptivecapacity and ...
Santos, Jane Lucia Silva
core  

Remaining Innovative: The Role of Past Performance, Absorptive Capacity, and Internationalization

BBR: Brazilian Business Review, 2017
Emerging markets firms are tardy regarding innovativeness and international orientation. Despite that, some of these firms are becoming increasingly competitive regarding innovation and internationalization.
Ivan Lapuente Garrido, Ronaldo Couto Parente, Cláudio Reis Gonçalo, Sílvio Luís de Vasconcellos   +3 more
doaj  

Unravelling the relationship between absorptive capacity, innovation, and financial performance: A longitudinal study

International Journal of Innovation Studies
This study explores the intricate relationships among absorptive capacity, innovation, and financial performance in nonfinancial firms. Using data from COMPUSTAT spanning 1966 to 2020, including 25,392 observations, Tobin's Q is used as a measure of ...
Mohammad Suleiman Awwad, Ala'a Adden Abuhommous, Ali Mohammad Adaileh   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cognitive social capital and new product performance: indirect effect of potential absorptive and innovation capacity: a tourism-based study [PDF]

European Journal of Management and Business Economics
PurposeThe purpose of this paper is to respond to the existing gap in the literature and analyze empirically the mediating role of potential absorptive capacity and innovation capacity in the relationship between socio-cognitive capital and new product ...
Patricia Pilar Zirena-Bejarano, Elbia Myreyle Chavez Zirena, Andrea Karina Caryt Malaga   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The Multinational Corporation and the Global Sourcing of Knowledge: Remodeling Absorptive Capacity [PDF]

We build on extant theory of the MNC, MNC subsidiaries, absorptive capacity and Penrose's concept of 'productive opportunity' to develop a framework on the MNC and absorptive capacity (AC) that allows us to explore the role of subsidiaries in the global ...
Papanastassiou, Marina, Pitelis, Christos, Kottaridi, Constantina, Thomakos, Dimitrios   +3 more
core  

Inter- and intra-firm learning synergy through integrating absorptive capacity and employee suggestion processes: The case study of Frauenthal Automotive Toruń company

Journal of Entrepreneurship, Management and Innovation, 2017
The aim of the paper is to study relationships between the processes of absorptive capacity (inter-firm learning) and learning lessons through employee suggestions (intra-firm learning) and identify potential synergies between them. The research interest
Andrzej Lis, Agata Sudolska
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source