Results 81 to 90 of about 84,179 (304)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Inter- and intra-firm learning synergy through integrating absorptive capacity and employee suggestion processes: The case study of Frauenthal Automotive Toruń company

Journal of Entrepreneurship, Management and Innovation, 2017
The aim of the paper is to study relationships between the processes of absorptive capacity (inter-firm learning) and learning lessons through employee suggestions (intra-firm learning) and identify potential synergies between them. The research interest
Andrzej Lis, Agata Sudolska
doaj   +1 more source

The Multinational Corporation and the Global Sourcing of Knowledge: Remodeling Absorptive Capacity [PDF]

We build on extant theory of the MNC, MNC subsidiaries, absorptive capacity and Penrose's concept of 'productive opportunity' to develop a framework on the MNC and absorptive capacity (AC) that allows us to explore the role of subsidiaries in the global ...
Kottaridi, Constantina, Papanastassiou, Marina, Pitelis, Christos, Thomakos, Dimitrios   +3 more
core  

Assessing the potential for knowledge-based development in transition countries. Bruegel Working Paper 2010/01, May 2010 [PDF]

, 2010
This Working Paper by Bruegel Senior Fellow Reinhilde Veugelers examines the potential for a knowledge-based growth path in transition countries of central and eastern Europe, the Caucasus and Central Asia.
Veugelers, Reinhilde.
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Regional innovation and spillover effects of foreign direct investment in China: a threshold approach [PDF]

, 2012
Using a data set on twenty-nine Chinese provinces for the period 1985–2008, this paper establishes a threshold model to analyse the relationship between spillover effects of foreign direct investment (FDI) and regional innovation in China. There is clear
Acs Z., Acs Z., Bengoa M., Blomström M., Blomström M., Cantwell J., Castellani D., Castellani D., Durham J. B., Edquist C., Ford T. C., Girma S., Griliches Z., Gu S., Guo B., Hansen B. E., Huang L., Huang Y., Jabbour L., Jaffe A., King R. G., Kinoshita Y., Kokko A., Lei Xu, Li X., Li X., Liang G., Lingyun Huang, Liu X., National Development and Reform Commission (NDRC), Olofsdotter K., Organisation for Economic Co-operation and Development (OECD), Walsh K., Wang C., Wang C., Wei Y., Wu Y., Xiaming Liu, Zhang J.   +38 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Do green dynamic capabilities and absorptive capacity affect green innovation performance? A study on companies in Indonesia

Journal of Industrial Engineering and Management
Purpose: This study aims to empirically analyze the effect of absorptive capacity, green dynamic capability, and green manufacturing practices (GMP) on green innovation performance (GIP). Design/methodology/approach: A quantitative approach was employed
Reni Amaranti, Rajesri Govindaraju, Dradjad Irianto   +2 more
doaj   +1 more source

ACAP MODEL AND INNOVATION IN U-I RELATIONSHIP

Contextus, 2018
The purpose of this study is to see how the relationship between universities and companies influences the latter’s absorptive capacity and therefore competitiveness.
Raquel Engelman, Dusan Schreiber
doaj   +1 more source