Results 61 to 70 of about 11,065,453 (296)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Remaining Innovative: The Role of Past Performance, Absorptive Capacity, and Internationalization

BBR: Brazilian Business Review, 2017
Emerging markets firms are tardy regarding innovativeness and international orientation. Despite that, some of these firms are becoming increasingly competitive regarding innovation and internationalization.
Ivan Lapuente Garrido, Ronaldo Couto Parente, Cláudio Reis Gonçalo, Sílvio Luís de Vasconcellos   +3 more
doaj  

Does absorptive capacity foster open innovation? Examining the impact of innovativeness and risk-taking on the innovative performance of tourism firms

Journal of Open Innovation: Technology, Market and Complexity
To maintain competitiveness and sustainability, firms must implement a combination of internal and external strategies that enhance their innovation potential. This study identifies absorptive capacity (ACAP) as a strategic antecedent of open innovation (
Bernardo De la Gala-Velásquez, Américo Hurtado-Palomino, Patricia Pilar Zirena-Bejarano, Angela Yuliana Arredondo-Salas   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Unravelling the relationship between absorptive capacity, innovation, and financial performance: A longitudinal study

International Journal of Innovation Studies
This study explores the intricate relationships among absorptive capacity, innovation, and financial performance in nonfinancial firms. Using data from COMPUSTAT spanning 1966 to 2020, including 25,392 observations, Tobin's Q is used as a measure of ...
Mohammad Suleiman Awwad, Ala'a Adden Abuhommous, Ali Mohammad Adaileh   +2 more
doaj   +1 more source

R&D Spillovers with Endogenous Absorptive Capacity: Lessons for Developing Countries

East Asian Economic Review, 2016
This paper analyzes the role of absorptive capacity in R&D spillovers through strategic R&D investments in a game-theoretic framework. In the model, a firm's effective R&D is composed of idiosyncratic R&D, which produces its own innovations, and ...
Chankwon Bae
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Exploring the Antecedents of Potential Absorptive Capacity and its Impact on Innovation Performance. [PDF]

This paper builds upon the theoretical framework developed by Zahra and George [Absorptive capacity: a review, reconceptualization, and extension.
Fosfuri, Andrea, Tribó, Josep A.
core  

The impact of dynamic marketing capabilities on startup performance: A case of business incubators in Jordan [PDF]

Innovative Marketing
Dynamic marketing capabilities provide startups with the platform and market knowledge that entitle them to achieve their goals and survive the competition.
Hamza Salim Khraim
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source