FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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Policy Analysis at OTA: A Staff Assessment, May 1993
, 1993 This document presents the findings of the Office of Technology Assessment (OTA) staff assessment of policy analysis that took place in 1992. It consisted of reviewing 18 sample OTA reports and soliciting opinions about OTA's policy analysis from outside
Office of Technology Assessment
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Hydrocarbon Potential Assessment of Carbonate-Bearing Sediments in a Meyal Oil Field, Pakistan: Insights from Logging Data Using Machine Learning and Quanti Elan Modeling. [PDF]
ACS Omega, 2022 Ali J +10 more
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
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Adaptive comparative judgement: Adapting adaptive assessment to assess the quality of students’ work
, 2012 It is increasingly acknowledged that adaptive assessment has a significant role to play in enhancing the assessment of and for learning. Computer adaptive testing (CAT) is a familiar method of delivering adaptive assessment, but it comes with a number of
Pollitt, Alastair, Wingfield, Matt
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Pathogenic potential assessment of the Shiga toxin-producing Escherichia coli by a source attribution-considered machine learning model. [PDF]
Proc Natl Acad Sci U S A, 2021 Im H, Hwang SH, Kim BS, Choi SH.
europepmc +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
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, 2012 This article investigates the impact on learning of generic feedback provided automatically after online selected response questions, such as multiple-choice or extended matching questions.
Dermo, John, Carpenter, Liz
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The use of behavioral economic demand in human abuse potential assessment: A review and recommendations for future testing. [PDF]
Exp Clin PsychopharmacolStrickland JC +15 more
europepmc +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
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