Results 181 to 190 of about 7,504,315 (296)

Metabolite characterization and in vitro antiplasmodial potential assessment of Sonchus arvensis L. callus under glutamine treatment. [PDF]

Sci Rep
Wahyuni DK, Rahmawati CT, Syukriya AJ, Dismayanti N, Arifin MB, Kharisma VD, Subramaniam S, Zakariya AM, Saiman MZ, Ikram NKK, Werbrouck SPO, Purnobasuki H, Prasongsuk S.   +12 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Divergent Avian Influenza H10 Viruses from Sympatric Waterbird Species in Italy: Zoonotic Potential Assessment by Molecular Markers. [PDF]

Microorganisms
Facchini M, De Marco MA, Piacentini S, Di Martino A, Gruber CEM, Cotti C, Di Mario G, Calzoletti L, Fabiani C, Delogu M, Palamara AT, Stefanelli P, Puzelli S.   +12 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Discriminating evidence - use and misuse of the drug-discrimination test in abuse potential assessment of novel CNS drugs. [PDF]

J Psychopharmacol
Heal DJ, Smith SL, Gosden J, Rowlett J.
europepmc   +1 more source

Quick extracellular biosynthesis of low-cadmium Zn _x Cd_1-x S quantum dots with full-visible-region tuneable high fluorescence and its application potential assessment in cell imaging. [PDF]

RSC Adv, 2021
Qi S, Chen J, Bai X, Miao Y, Yang S, Qian C, Wu B, Li Y, Xin B.   +8 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

CO2 geological storage site selection and long-term potential assessment framework based on TOUGH2/ECO2N. [PDF]

PLoS One
Sun W, Liu W, Ren S, Lin G, Wang C, Jiang X.   +5 more
europepmc   +1 more source

Assessment of steam-injected gas turbine systems and their potential application [PDF]

Results were arrived at by utilizing and expanding on information presented in the literature. The results were analyzed and compared with those for simple gas turbine and combined cycles for both utility power generation and industrial cogeneration ...
Stochl, R. J.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source