Results 61 to 70 of about 16,411,473 (263)

Asthma exacerbation due to climate change-induced wildfire smoke in the Western US

open access: yesEnvironmental Research Letters, 2021
Climate change and human activities have drastically altered the natural wildfire balance in the Western US and increased population health risks due to exposure to pollutants from fire smoke.
Jennifer D Stowell   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

FUE Movie

open access: yes, 2016
Head Masters Of CollegesFuture University in Egypt is one of the newest and most promising private universities in Egypt. The FUE campus is conveniently located in the heart of New Cairo.
Future University In Egypt
core  

ROMANIA’S LABOUR MARKET EXPOSURE TO AI [PDF]

open access: yesAnnals of the University of Oradea: Economic Science
New technologies are significant drivers of contemporary social transformations. These changes often lead to predictions about the future of jobs, primarily based on historical analogies and ideological suppositions.
Ludovic DIOSZEGI
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Latest research progress on effects of prenatal bisphenol S exposure on offspring's glucose metabolism

open access: yes环境与职业医学
Bisphenol S (BPS), a major substitute for bisphenol A (BPA), is widely used in the production of plastics, thermal paper, and epoxy resins, and is ubiquitous in air, soil, water, and food.
Zishun LU, Chao ZHANG, Jiahu HAO
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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