Results 121 to 130 of about 1,074,642 (303)

First-order methods of smooth convex optimization with inexact oracle [PDF]

In this paper, we analyze different first-order methods of smooth convex optimization employing inexact first-order information. We introduce the notion of an approximate first-order oracle.
GLINEUR, François, NESTEROV, Yurii, DEVOLDER, Olivier   +2 more
core  

Variability and trends in the potential vorticity (PV)-gradient dynamical tropopause [PDF]

Atmospheric Chemistry and Physics
The dynamical tropopause acts as a transport barrier between the tropical upper troposphere and extratropical lowermost stratosphere and is characterized by steep gradients in potential vorticity (PV) along an isentropic surface.
K. Turhal, K. Turhal, F. Plöger, F. Plöger, J. Clemens, J. Clemens, T. Birner, T. Birner, F. Weyland, P. Konopka, P. Hoor   +10 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

High-Frequency Response of the Atmospheric Electric Potential Gradient Under Strong and Dry Boundary-Layer Convection [PDF]

, 2017
The spectral response of atmospheric electric potential gradient gives important information about phenomena affecting this gradient at characteristic time scales ranging from years (e.g., solarmodulation) to fractions of a second (e.g., turbulence ...
Maria João Costa, Salgado, Rui, Alec Bennett, Hugo Gonçalves Silva, Manuel Collares Pereira, Bortoli, Daniele, Costa, Maria João, Silva, Hugo, Colares-Pereira, Manueal, Collares Pereira, Manuel, Ricardo Conceição, Conceição, Ricardo, Daniele Bortoli, Bennett, Alec, Rui Salgado   +14 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The design and additive manufacture of gradient dielectrics for RF devices [PDF]

Mirotznik, Mark S.Gradient dielectrics have emerged as effective constructs for the design and optimization of broadband radio frequency (RF) devices. Their ability to enhance performance and reduce physical footprints is exemplified in applications such
Fessaras, Theodore N.Z.
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Dynamic surface potential gradient for charged droplet manipulation [PDF]

Droplet manipulation with specific functionalities expands its practical applications. This study combines droplet motion and reactivity through a dynamic surface potential gradient.
Hu, Xuanming, Feng, Haiye, He, Lirong, Sun, Qiangqiang, Sun, Guo, Zhou, Shaobing, Tang, Yunxin, Lin, Shiji, Wang, Jie   +8 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source