Results 111 to 120 of about 10,584,442 (302)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Stomatal responses of tree species from the cloud forest in central Veracruz, México

Botan‪ical Sciences, 2016
Stomatal conductance is considered as a key plant response because it plays an important role in plant physiology by controlling transpiration (water status) and CO2 assimilation, regulating plant productivity.
Manuel Esperón-Rodríguez, Víctor L. Barradas   +1 more
doaj   +1 more source

Direct evidence for dynamics of cell heterogeneity in watercored apples: turgor-associated metabolic modifications and within-fruit water potential gradient unveiled by single-cell analyses. [PDF]

Hortic Res, 2021
Wada H, Nakata K, Nonami H, Erra-Balsells R, Tatsuki M, Hatakeyama Y, Tanaka F.   +6 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Predictability of carbon assimilation in high biodiversity ecosystems within the context of climate change

Global Ecology and Conservation
There is an increasing need to assess carbon exchange capacity of natural ecosystems in the context of a changing climate, which is crucial for understanding their future carbon capture potential and conservation.
Alicia V. Perera-Castro, Laura Díaz-Jiménez, Yauci Espinosa-González, Jaime Puértolas, Beatriz Fernández-Marín, Águeda M. González-Rodríguez   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Gradient Flows of Potential Energies in the Geometry of Sinkhorn Divergences

We analyze the gradient flow of a potential energy in the space of probability measures when we substitute the optimal transport geometry with a geometry based on Sinkhorn divergences, a debiased version of entropic optimal transport.
Lavenant, Hugo, Hardion, Mathis
core   +4 more sources

Variability and trends in the potential vorticity (PV)-gradient dynamical tropopause [PDF]

Atmospheric Chemistry and Physics
The dynamical tropopause acts as a transport barrier between the tropical upper troposphere and extratropical lowermost stratosphere and is characterized by steep gradients in potential vorticity (PV) along an isentropic surface.
K. Turhal, K. Turhal, F. Plöger, F. Plöger, J. Clemens, J. Clemens, T. Birner, T. Birner, F. Weyland, P. Konopka, P. Hoor   +10 more
doaj   +1 more source

Motion Driven by Strain Gradient Fields [PDF]

, 2015
A new driving mechanism for direction-controlled motion of nano-scale objects is proposed, based on a model of stretching a graphene strip linked to a rigid base with linear springs of identical stiffness.
Chen, Shaohua, Wang, Chao, Chen, SH (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China., Shaohua Chen, Chao Wang   +4 more
core   +1 more source