Results 111 to 120 of about 10,111,763 (293)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Formulation, analysis and solution algorithms for a model of gradient plasticity within a discontinuous Galerkin framework [PDF]
, 2008 Includes bibliographical references (p. [221]-239).An investigation of a model of gradient plasticity in which the classical von Mises yield function is augmented by a term involving the Laplacian of the equivalent plastic strain is presented. The theory
McBride, Andrew Trevor
core +1 more source
Analytical solutions for the internal and external gravitation of a homogeneous cuboid
Journal of Geodetic ScienceWe extend our previous formulation of the gravitational potential of a homogeneous cuboid (right rectangular prism) by deriving uniform analytical expressions for the gravitational acceleration and the full gravitational tensor.
Periyandy Thunendran, Bevis Michael
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Figure 2: Path-Gradient-Planning - Situational Gradient Norms
Path-Gradient Norms for Grid-world environments show in Figure 1.E-OEach frame represents the heat-map of gradient norms for each state over training steps. Gradients were computed using Path-Gradient Planning with situational focus.
Francesco Trapani (16642515)
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Figure 3: Path-Gradient-Planning - Allocentric Gradient Norms
Path-Gradient Norms for Grid-world environments show in Figure 1.E-OEach frame represents the heat-map of gradient norms for each state over training steps.
Francesco Trapani (16642515)
core +1 more source