Results 131 to 140 of about 10,111,763 (293)

Gradient descent Sarsa(?)algorithm based on the adaptive potential function shaping reward mechanism

Tongxin xuebao, 2013
In the reinforcement leaning tasks with continuous state spaces,the algorithms are usually facing the problems of ill initial performance and low convergence speed.In order to solve these problems,the potential function shaping reward mechanism was ...
Fei XIAO, Quan LIU, Qi-ming FU, Hong-kun SUN, Long GAO   +4 more
doaj   +2 more sources

Autonomous Enrichment of Ultra-low Concentration Sb(III) by Gradient P(AA-AM-NH2-β-CD) Hydrogels Reinforced via Hofmeister Effect

Engineered Science
Gradient hydrogels offer significant promise for autonomous enrichment of heavy metal ions. However, the instability of the gradient hydrogel induced by high osmotic pressure limits its application, especially for the enrichment of ultra-trace levels of ...
Zihan Han, Yuhan Zhang, Qianyuan Wang, Wenhui Zhang, Kunyan Sui, Pengfei Qi   +5 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Investigation of sound propagation in a duct with a mean temperature gradient [PDF]

, 2014
This paper presents an analytical and numerical investigation of an impedance tube in the presence of a mean temperature gradient. Full Navier-Stokes simulation of the acoustic wave propagations through an impedance tube in the presence of a mean ...
Aygun, Haydar
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A Colour Interpolation Scheme for Topologically Unrestricted Gradient Meshes

, 2017
Gradient meshes are a 2D vector graphics primitive where colour is interpolated between mesh vertices. The current implementations of gradient meshes are restricted to rectangular mesh topology.
Shen, Jingjing, Kosinka, Jiří, Lieng, Henrik, Dodgson, Neil A.   +3 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Lusin-type theorem for functions with prescribed gradient [PDF]

openIn the first part of this thesis we discuss and prove a theorem by Giovanni Alberti whose statement shares similarities to that of Lusin's Theorem, hence the "Lusin-type theorem" definition.
PRATI, EMANUELE
core