Results 121 to 130 of about 2,560,790 (243)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Invited Perspective: The Potential of Potential Outcomes in Air Pollution Epidemiology
Environmental Health Perspectives, 2023 openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Labour market outcomes and Egypt's migration potential
, 2014 Will the radical political changes Egypt has gone through since early 2011 have an impact on emigration from the country? This all depends on young Egyptian adults, who are the potential migrants of tomorrow. In order to understand the consequences of the Egyptian revolution might for migration, a questionnaire survey was conducted amongst Egyptian ...
Mona Amer, Philippe Fargues
openaire +1 more source
TMPRSS2: Potential Biomarker for COVID‐19 Outcomes [PDF]
The Journal of Clinical Pharmacology, 2020 Strope, Jonathan D. +2 more
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Assessing post-cold challenge recovery of thermography as a potential outcome measure in trials of SSc-related Raynaud's phenomenon. [PDF]
Sci RepNdosi AA +6 more
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Correction: Discovery of genes positively modulating treatment effect using potential outcome framework and Bayesian update. [PDF]
BMC Med Inform Decis MakLee Y, Kim J, Seo SW.
europepmc +1 more source